{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:08:26Z","timestamp":1777918106971,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1981,2,1]],"date-time":"1981-02-01T00:00:00Z","timestamp":349833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1981,2]]},"abstract":"<jats:p>Fifteen of 146 (10 %) adult patients with non-Hodgkin's lymphoma showed clinical and pathologic evidence of involvement of the central nervous system (CNS); in 6 patients, the CNS lymphoma was present at the onset of disease, in 3 of them it was the only sign detected. In the remaining 9 cases, CNS involvement appeared during the course of systemic disease. In all cases symptoms related to infiltration of the CNS were associated with advanced disease (stage IV); bone marrow or bone involvement was found in 9 patients (60 %). The histologic subtypes were mostly of high-grade malignancy according to the Kiel classification: immunoblastic (3), centroblastic (3), Burkitt type (2), lymphoblastic (1), LP immunocytoma in polymorphic variant (3), unclassifiable (3). The prominent signs and symptoms of CNS lymphoma are listed: the cranial nerve palsies are the most common finding. The principal means of detecting CNS involvement are discussed: cerebrospinal fluid cytology, brain scan and CAT scan were the most useful diagnostic procedures. The reported data allow identification of patients at high risk of CNS lymphoma: this includes histologies of high-grade malignancy, advanced stage of disease, and bone marrow or bone infiltration. Therefore, either intensive systemic chemotherapy or CNS prophylaxis are recommended for patients with high risk of CNS disease.<\/jats:p>","DOI":"10.1177\/030089168106700108","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:26:51Z","timestamp":1523881611000},"page":"39-44","source":"Crossref","is-referenced-by-count":5,"title":["Involvement of the Central Nervous System in Non-Hodgkin's Lymphoma"],"prefix":"10.1177","volume":"67","author":[{"given":"Gian Luigi","family":"Cetto","sequence":"first","affiliation":[{"name":"Haematology Section, University, Padova, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Iannucci","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University, Padova, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Tummarello","sequence":"additional","affiliation":[{"name":"Haematology Section, University, Padova, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Rizzuto","sequence":"additional","affiliation":[{"name":"Institute of Neurology, University, Padova, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Sabbioni","sequence":"additional","affiliation":[{"name":"Haematology Section, University, Padova, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Menestrina","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University, Padova, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1981,2,1]]},"reference":[{"key":"bibr1-030089168106700108","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V47.1.3.3"},{"key":"bibr2-030089168106700108","first-page":"1860","volume":"31","author":"Carbone P.P.","year":"1971","journal-title":"Cancer Res."},{"key":"bibr3-030089168106700108","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1105518"},{"key":"bibr4-030089168106700108","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196910)24:4<676::AID-CNCR2820240404>3.0.CO;2-V"},{"key":"bibr5-030089168106700108","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197410)34:4<1293::AID-CNCR2820340441>3.0.CO;2-P"},{"key":"bibr6-030089168106700108","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197901)43:1<390::AID-CNCR2820430155>3.0.CO;2-U"},{"key":"bibr7-030089168106700108","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.2820360929"},{"key":"bibr8-030089168106700108","first-page":"194","volume":"50","author":"Jones S.E.","year":"1977","journal-title":"(Abstract). 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