{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:08:58Z","timestamp":1777918138201,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1982,10,1]],"date-time":"1982-10-01T00:00:00Z","timestamp":402278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1982,10]]},"abstract":"<jats:p>\n                    Twelve adult patients with acute lymphoblastic leukemia (ALL) received lithium carbonate, 300 mg, three times a day during induction treatment. They were compared to 12 similar patients consecutively treated with the same induction regimen; patients and controls were comparable for age, degree and presence of splenomegaly, hemoglobin level, blast cell count, polymorphonuclear (PMN) cell count and platelet count at diagnosis. All patients developed a severe neutropenia. PMN count at nadir was slightly higher in the lithium group, but not at a level of statistical significance (p = 0.100). The median number of days with PMN &lt; 1 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/liter was 4 in the lithium group and 14.5 in the non-lithium group (p = 0.014), while the median number of days with PMN &lt; 0.5 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/liter was 0 and 2 days, respectively (p = 0.004). Duration of thrombocytopenia was similar in the 2 groups and so was the remission rate; 2 infective episodes occurred, one in the lithium group and one in the controls.\n                  <\/jats:p>","DOI":"10.1177\/030089168206800512","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:14:58Z","timestamp":1523880898000},"page":"427-430","source":"Crossref","is-referenced-by-count":3,"title":["Lithium and Granulocytopenia during Induction Treatment of Adult Acute Lymphoblastic Leukemia"],"prefix":"10.1177","volume":"68","author":[{"given":"Giuseppe","family":"Bandini","sequence":"first","affiliation":[{"name":"(Istituto di Ematologia \u00ab Lorenzo e Ariosto Ser\u00e0gnoli \u00bb, Universit\u00e0 Policlinico S. Orsola, Bologna)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Ricci","sequence":"additional","affiliation":[{"name":"(Istituto di Ematologia \u00ab Lorenzo e Ariosto Ser\u00e0gnoli \u00bb, Universit\u00e0 Policlinico S. Orsola, Bologna)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatella","family":"Ruggero","sequence":"additional","affiliation":[{"name":"(Istituto di Ematologia \u00ab Lorenzo e Ariosto Ser\u00e0gnoli \u00bb, Universit\u00e0 Policlinico S. Orsola, Bologna)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Cantore","sequence":"additional","affiliation":[{"name":"(Istituto di Ematologia \u00ab Lorenzo e Ariosto Ser\u00e0gnoli \u00bb, Universit\u00e0 Policlinico S. Orsola, Bologna)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Visani","sequence":"additional","affiliation":[{"name":"(Istituto di Ematologia \u00ab Lorenzo e Ariosto Ser\u00e0gnoli \u00bb, Universit\u00e0 Policlinico S. Orsola, Bologna)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sante","family":"Tura","sequence":"additional","affiliation":[{"name":"(Istituto di Ematologia \u00ab Lorenzo e Ariosto Ser\u00e0gnoli \u00bb, Universit\u00e0 Policlinico S. Orsola, Bologna)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1982,10,1]]},"reference":[{"key":"bibr1-030089168206800512","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)92093-0"},{"key":"bibr2-030089168206800512","doi-asserted-by":"publisher","DOI":"10.1007\/BF01028358"},{"key":"bibr3-030089168206800512","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03563.x"},{"key":"bibr4-030089168206800512","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197909063011020"},{"key":"bibr5-030089168206800512","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197508)36:2+<775::AID-CNCR2820360824>3.0.CO;2-V"},{"key":"bibr6-030089168206800512","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198004033021413"},{"key":"bibr7-030089168206800512","first-page":"199","volume":"1","author":"Lister T.A.","year":"1979","journal-title":"Br. Med. 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