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The treatment induced a significant increase in lung tumors in male mice (p &lt; 0.001) and provoked the appearance of lymphomas in females (p &lt; 0.001). Although there is insufficient evidence to pass judgement on the potential carcinogenicity of metronidazole in man, the results of this and other investigations reported in the literature have demonstrated that metronidazole develops carcinogenic activity in rats and mice.<\/jats:p>","DOI":"10.1177\/030089168306900502","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T11:15:08Z","timestamp":1524482108000},"page":"379-382","source":"Crossref","is-referenced-by-count":25,"title":["Induction of Lung Tumors and Lymphomas in BALB\/c Mice by Metronidazole"],"prefix":"10.1177","volume":"69","author":[{"given":"Antonio","family":"Cavaliere","sequence":"first","affiliation":[{"name":"Istituto di Anatomia e Istologia Patologica, Divisione di Ricerche sul Cancro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Bacci","sequence":"additional","affiliation":[{"name":"Istituto di Anatomia e Istologia Patologica, Divisione di Ricerche sul Cancro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Amorosi","sequence":"additional","affiliation":[{"name":"Istituto di Anatomia e Istologia Patologica, Divisione di Ricerche sul Cancro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Del Gaudio","sequence":"additional","affiliation":[{"name":"Istituto di Anatomia e Istologia Patologica, Divisione di Ricerche sul Cancro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rino","family":"Vitali","sequence":"additional","affiliation":[{"name":"Istituto di Igiene, Universit\u00e0 di Perugia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1983,10,1]]},"reference":[{"key":"bibr1-030089168306900502","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197909063011003"},{"key":"bibr2-030089168306900502","first-page":"629","volume":"37","author":"Connor T.H.","year":"1977","journal-title":"Cancer Res."},{"key":"bibr3-030089168306900502","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198002283020911"},{"key":"bibr4-030089168306900502","unstructured":"GoodmanL.S., GilmanA.: The Pharmacological Basis of Therapeutics, pp. 1072\u20131073, 1086\u20131088, MacMillan, New York, 1975."},{"key":"bibr5-030089168306900502","first-page":"909","volume":"10","author":"Jackson B.","year":"1961","journal-title":"Lab. 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