{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:09:35Z","timestamp":1777918175561,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1984,2,1]],"date-time":"1984-02-01T00:00:00Z","timestamp":444441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1984,2]]},"abstract":"<jats:p>\n                    The effects of medroxyprogesterone acetate (MPA) on differentiation were examined using mouse erythroleukemia (MEL) cells and compared with those of antiinflammatory agents. MPA at low doses (10\n                    <jats:sup>\u22126<\/jats:sup>\n                    - 10\n                    <jats:sup>\u22127<\/jats:sup>\n                    M) induced 10\u201315 % cells to differentiate, whereas high doses (10\n                    <jats:sup>\u22124<\/jats:sup>\n                    - 10\n                    <jats:sup>\u22125<\/jats:sup>\n                    M) caused a 30 % inhibition of dimethylsulfoxide (DMSO)-induced differentiation. Dexamethasone (10\n                    <jats:sup>\u22124<\/jats:sup>\n                    - 10\n                    <jats:sup>\u22128<\/jats:sup>\n                    M), a steroid antiinflammatory agent, significantly inhibited (77\u201370 %) DMSO-induced differentiation, whereas indomethacin, aspirin, flurbiprofen and BW755c (non steroid antiinflammatory agents) at the same concentrations had no effect. If added 24 h before DMSO, the inhibitory effects of MPA and dexamethasone increased to 65 % and 95 %, respectively, whereas indomethacin (10\n                    <jats:sup>\u22125<\/jats:sup>\n                    M) caused only a 30 % inhibition and the other drugs were inactive. None of these antiinflammatory agents affected differentiation when used without DMSO. MPA and dexamethasone inhibitory effects on DMSO-induced differentiation did not seem to be mediated through the inhibition of the synthesis of prostaglandins, since non-steroid prostaglandin inhibitors were slighly active only when added 24 h before DMSO.\n                  <\/jats:p>","DOI":"10.1177\/030089168407000103","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:32:19Z","timestamp":1523943139000},"page":"17-21","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Medroxyprogesterone Acetate and of Some Antiinflammatory Agents on Mouse Erythroleukemia Cell Differentiation"],"prefix":"10.1177","volume":"70","author":[{"given":"Rosanna","family":"Supino","sequence":"first","affiliation":[{"name":"Division of Experimental Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Mazzoni","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franca","family":"Formelli","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1984,2,1]]},"reference":[{"key":"bibr1-030089168407000103","doi-asserted-by":"publisher","DOI":"10.1007\/BF02892565"},{"key":"bibr2-030089168407000103","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(78)90006-9"},{"key":"bibr3-030089168407000103","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.90.2.542"},{"key":"bibr4-030089168407000103","doi-asserted-by":"publisher","DOI":"10.1007\/BF00258291"},{"key":"bibr5-030089168407000103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1980.tb01809.x"},{"key":"bibr6-030089168407000103","first-page":"232","volume":"3","author":"Formelli F.","year":"1979","journal-title":"Chemioter. 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Minerva Ginecol."},{"key":"bibr16-030089168407000103","first-page":"325","volume":"605","author":"Reuben R.C.","year":"1980","journal-title":"Biochim. Biophys. 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