{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:09:39Z","timestamp":1777918179485,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1984,4,1]],"date-time":"1984-04-01T00:00:00Z","timestamp":449625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1984,4]]},"abstract":"<jats:p>Forty patients with leukemia or aplastic anemia were randomized to receive one of the following antibiotic regimens at the onset of fever during granulocytopenia: cefoperazone + amikacin (regimen A), cefoperazone + sisomicin (regimen B), cefotaxime + amikacin (regimen C), cefotaxime + sisomicin (regimen D). All patients were receiving gut decontamination at the time of randomization. Patients were monitored twice weekly with swabs and cultures for bacteria and fungi. Overall, there were 56 febrile episodes: 31 were proven bacterial, 3 were probable, and 16 were of unknown origin. Response rates were comparable in all 4 treatment regimens: 90 %, 91 %, 92 % and 92 %, respectively. Three patients died of bacterial infections (2 Gram +, 1 Gram-), one patient died with probable infection, 6 febrile episodes were related to fungal infection (Candida), and 2 patients died. The mortality rate was comparable in all groups. Two patients died of renal failure. Abnormalities in liver function tests were observed, but were without consequences. There were no statistical differences in renal-hepatic toxicity in the 4 arms.<\/jats:p>","DOI":"10.1177\/030089168407000208","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:34:32Z","timestamp":1523943272000},"page":"151-158","source":"Crossref","is-referenced-by-count":0,"title":["Cefoperazone versus Cefotaxime, plus Amikacin or Sisomicin, in Fever and Infection in Hematologic Granulocytopenic Patients"],"prefix":"10.1177","volume":"70","author":[{"given":"Gino","family":"Santini","sequence":"first","affiliation":[{"name":"Divisione di Ematologia ed Immunologia Clinica, Ospedale San Martino, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Michele","family":"Cardella","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia ed Immunologia Clinica, Ospedale San Martino, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bacigalupo","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia ed Immunologia Clinica, Ospedale San Martino, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.T.","family":"Van Lint","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia ed Immunologia Clinica, Ospedale San Martino, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Marina","family":"Congni","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia ed Immunologia Clinica, Ospedale San Martino, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Occhini","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia ed Immunologia Clinica, Ospedale San Martino, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Costa","sequence":"additional","affiliation":[{"name":"Servizio di Analisi Clinico-chimiche e Microbiologiche, Ospedale San Martino, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Sbaffi","sequence":"additional","affiliation":[{"name":"Servizio di Analisi Clinico-chimiche e Microbiologiche, Ospedale San Martino, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Accontero","sequence":"additional","affiliation":[{"name":"Servizio di Analisi Clinico-chimiche e Microbiologiche, Ospedale San Martino, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Sdutto","sequence":"additional","affiliation":[{"name":"Servizio di Analisi Clinico-chimiche e Microbiologiche, Ospedale San Martino, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Giordano","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia ed Immunologia Clinica, Ospedale San Martino, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Cerri","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia ed Immunologia Clinica, Ospedale San Martino, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Risso","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia ed Immunologia Clinica, Ospedale San Martino, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Nati","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia ed Immunologia Clinica, Ospedale San Martino, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Mario","family":"Marmont","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia ed Immunologia Clinica, Ospedale San Martino, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1984,4,1]]},"reference":[{"key":"bibr1-030089168407000208","first-page":"559","volume":"8","author":"Acar J.F.","year":"1981","journal-title":"Nouv. Presse M\u00e9d., \u00ab Num\u00e9ro supplementaire consacr\u00e9 au Cefotaxime \u00bb"},{"issue":"1","key":"bibr2-030089168407000208","first-page":"160","volume":"28","author":"Aimano R.","year":"1980","journal-title":"Chemotherapy (Tokyo)"},{"key":"bibr3-030089168407000208","first-page":"168","volume":"41","author":"Bacigalupo A.","year":"1980","journal-title":"Blut"},{"key":"bibr4-030089168407000208","doi-asserted-by":"publisher","DOI":"10.1177\/030089168106700603"},{"key":"bibr5-030089168407000208","doi-asserted-by":"publisher","DOI":"10.1007\/BF01639402"},{"key":"bibr6-030089168407000208","first-page":"1610","volume":"41","author":"Bodey G.P.","year":"1978","journal-title":"A study of 494 consecutive patients. Cancer"},{"key":"bibr7-030089168407000208","first-page":"620","volume":"68","author":"Carella A.M.","year":"1983","journal-title":"Studio pilota in 18 casi. Haematologica"},{"key":"bibr8-030089168407000208","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197605000-00005"},{"key":"bibr9-030089168407000208","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/137.1.14"},{"key":"bibr10-030089168407000208","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.17.2.273"},{"key":"bibr11-030089168407000208","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.17.4.743"},{"key":"bibr12-030089168407000208","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197903000-00004"},{"key":"bibr13-030089168407000208","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1974.03230140019004"},{"key":"bibr14-030089168407000208","doi-asserted-by":"publisher","DOI":"10.1159\/000207557"},{"key":"bibr15-030089168407000208","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90594-0"},{"key":"bibr16-030089168407000208","first-page":"151","volume-title":"\u00ab Corso di Aggiornamento in Ematologia Oncologica Biologia e Clinica \u00bb","author":"Santini G.","year":"1982"},{"key":"bibr17-030089168407000208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197105132841904"},{"key":"bibr18-030089168407000208","first-page":"60","volume":"3","author":"Shimizu K.","year":"1980","journal-title":"\u00ab Special issue on cefoperazone sodium: Proceedings of the first international Symposium, Boston, October, 1979 \u00bb, Clin. Ther."},{"key":"bibr19-030089168407000208","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1975.00330050089015"},{"key":"bibr20-030089168407000208","first-page":"983","volume":"71","author":"Wade J.C.","year":"1981","journal-title":"A double-blind prospective comparison of empiric antibiotic therapy for febrile granulocytopenic cancer patients. Am. J. Med."}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089168407000208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089168407000208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:33:02Z","timestamp":1777660382000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089168407000208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,4]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,4]]}},"alternative-id":["10.1177\/030089168407000208"],"URL":"https:\/\/doi.org\/10.1177\/030089168407000208","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,4]]}}}