{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:09:56Z","timestamp":1777918196515,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1984,8,1]],"date-time":"1984-08-01T00:00:00Z","timestamp":460166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1984,8]]},"abstract":"<jats:p>\n                    In the present study we investigated the lymph node morphology and distribution of cell surface phenotypes in four cases of adult peripheral T cell lymphoma. Histologically, the tumors were classified as T zone lymphoma, T cell lymphoma with large multilobated nuclei and T cell immunoblastic sarcoma. In the T zone lymphoma the neoplastic lymphocytes were E\n                    <jats:sup>+<\/jats:sup>\n                    (90 %) and exhibited intensive focal staining for acid phosphatase (93 %) and acid esterase (92 %); the phenotype distribution revealed low expression of the T-3 antigen (49 %), selective expression of the T-4 antigen (72 %) and poor expression of T-6 (10 %) and T-10 antigens (22 %). Some of these features are present in normal and in neoplastic immature T cells. In the remaining three cases the majority of lymph node cells were E\n                    <jats:sup>+<\/jats:sup>\n                    (59\u201375 %), T-3\n                    <jats:sup>+<\/jats:sup>\n                    (67\u201380 %) and T-8\n                    <jats:sup>+<\/jats:sup>\n                    (43\u201355 %). A distinctive feature of the T cell immunoblastic sarcoma was the presence of high percentages of DR\n                    <jats:sup>+<\/jats:sup>\n                    cells (62 %; 63 %). Thus our results indicate that the morphological heterogeneity of peripheral T cell lymphoma is also paralleled by a variety of surface phenotypes and that phenotype studies may provide a useful contribution to identification and accurate classification of peripheral T cell neoplasms.\n                  <\/jats:p>","DOI":"10.1177\/030089168407000409","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:34:34Z","timestamp":1523943274000},"page":"345-353","source":"Crossref","is-referenced-by-count":2,"title":["Peripheral T Cell Lymphoma in Adults: Morphological and Phenotypical Study of Four Cases"],"prefix":"10.1177","volume":"70","author":[{"given":"Luigi P.","family":"Ruco","sequence":"first","affiliation":[{"name":"Immunopathology Sections, Department of Human Biopathology, School of Medicine, University \u00ab La Sapienza \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Stoppacciaro","sequence":"additional","affiliation":[{"name":"Immunopathology Sections, Department of Human Biopathology, School of Medicine, University \u00ab La Sapienza \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Mirolo","sequence":"additional","affiliation":[{"name":"Immunopathology Sections, Department of Human Biopathology, School of Medicine, University \u00ab La Sapienza \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Valtieri","sequence":"additional","affiliation":[{"name":"Immunopathology Sections, Department of Human Biopathology, School of Medicine, University \u00ab La Sapienza \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Vitolo","sequence":"additional","affiliation":[{"name":"Immunopathology Sections, Department of Human Biopathology, School of Medicine, University \u00ab La Sapienza \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Uccini","sequence":"additional","affiliation":[{"name":"Immunopathology Sections, Department of Human Biopathology, School of Medicine, University \u00ab La Sapienza \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Paola","family":"Anselmo","sequence":"additional","affiliation":[{"name":"Hematology Sections, Department of Human Biopathology, School of Medicine, University \u00ab La Sapienza \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Guglielmi","sequence":"additional","affiliation":[{"name":"Hematology Sections, Department of Human Biopathology, School of Medicine, University \u00ab La Sapienza \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Mandelli","sequence":"additional","affiliation":[{"name":"Hematology Sections, Department of Human Biopathology, School of Medicine, University \u00ab La Sapienza \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo D.","family":"Baroni","sequence":"additional","affiliation":[{"name":"Immunopathology Sections, Department of Human Biopathology, School of Medicine, University \u00ab La Sapienza \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1984,8,1]]},"reference":[{"key":"bibr1-030089168407000409","first-page":"55","author":"Amadori S.","year":"1981","journal-title":"International Conference on Malignant Lymphoma"},{"key":"bibr2-030089168407000409","first-page":"147","volume-title":"Conflicts in Childhood Cancer; An evaluation of current management","volume":"4","author":"Barcos M.P.","year":"1975"},{"key":"bibr3-030089168407000409","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V57.6.1105.1105"},{"key":"bibr4-030089168407000409","first-page":"167","volume":"144","author":"Billing R.","year":"1976","journal-title":"I. 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