{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:10:27Z","timestamp":1777918227993,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1985,2,1]],"date-time":"1985-02-01T00:00:00Z","timestamp":476064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1985,2]]},"abstract":"<jats:p>To test the relationship between tumor malignancy and content and distribution of polyamines and nucleic acids, 2 forms of human gestational trophoblastic tumors were examined: the hydatidiform mole (self-limited form) and the human choriocarcinoma (invasive form) xenografted into nude mice. The results indicate that there are 2 significant differences between the choriocarcinoma and the mole: 1) the choriocarcinoma is characterized by increased polyamine and nucleic acid levels, 2) the 2 tissues differ in their putrescine:spermidine and spermidine:spermine ratios. There is an increase in polyamines in the urine of mole-bearing patients over that of normal controls. The correlation between putrescine and spermidine with the chorionic gonadotropin indicates that these 2 polyamines reflect the biological activity of the mole.<\/jats:p>","DOI":"10.1177\/030089168507100106","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:26:54Z","timestamp":1523942814000},"page":"35-38","source":"Crossref","is-referenced-by-count":1,"title":["Polyamines and Nucleic Acids in Gestational Trophoblastic Tumors"],"prefix":"10.1177","volume":"71","author":[{"given":"Marta","family":"Romano","sequence":"first","affiliation":[{"name":"Divisione di Biochimica, Istituto dei Tumori di Napoli"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Cecco","sequence":"additional","affiliation":[{"name":"Divisione di Biochimica, Istituto dei Tumori di Napoli"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Cerra","sequence":"additional","affiliation":[{"name":"Divisione di Biochimica, Istituto dei Tumori di Napoli"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Pasquinelli","sequence":"additional","affiliation":[{"name":"Divisione di Biochimica, Istituto dei Tumori di Napoli"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Michelangelo","family":"Pagnano","sequence":"additional","affiliation":[{"name":"Divisione di Puericultura Prenatale, II Facolt\u00e0 di Medicina, Universt\u00e0 di Napoli"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Paladini","sequence":"additional","affiliation":[{"name":"Divisione di Puericultura Prenatale, II Facolt\u00e0 di Medicina, Universt\u00e0 di Napoli"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1985,2,1]]},"reference":[{"key":"bibr1-030089168507100106","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1967.tb03995.x"},{"key":"bibr2-030089168507100106","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(72)90253-X"},{"key":"bibr3-030089168507100106","first-page":"315","volume":"62","author":"Burton K.","year":"1955","journal-title":"J."},{"key":"bibr4-030089168507100106","first-page":"214","volume":"37","author":"Durie B.G.M.","year":"1977","journal-title":"Cancer Res."},{"key":"bibr5-030089168507100106","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(75)81026-X"},{"key":"bibr6-030089168507100106","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1981.tb01123.x"},{"key":"bibr7-030089168507100106","first-page":"243","volume-title":"Polyamine in Biology and Medicine","author":"Heby O.","year":"1981"},{"key":"bibr8-030089168507100106","first-page":"426","volume":"58","author":"Owen J.A.","year":"1954","journal-title":"J."},{"key":"bibr9-030089168507100106","doi-asserted-by":"publisher","DOI":"10.1177\/030089168006600602"},{"key":"bibr10-030089168507100106","doi-asserted-by":"publisher","DOI":"10.1177\/030089168106700507"},{"key":"bibr11-030089168507100106","first-page":"456458","volume":"31","author":"Romano M.","year":"1982","journal-title":"Ital. 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