{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:10:26Z","timestamp":1777918226078,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1985,4,1]],"date-time":"1985-04-01T00:00:00Z","timestamp":481161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1985,4]]},"abstract":"<jats:p>\n                    (BALB\/c \u00d7 C3Hf) (H-2\n                    <jats:sup>d<\/jats:sup>\n                    \u00d7 H-2\n                    <jats:sup>k<\/jats:sup>\n                    )F1 hybrid mice but not parental BALB\/c or other BALB\/c \u00d7 H-2\n                    <jats:sup>k<\/jats:sup>\n                    F1 hybrids, were unresponsive in transplantation and in neutralization (Winn) assay against a 3-methylcholanthrene-induced BALB\/c fibrosarcoma. In BALB\/c mice the antitumor activity revealed by Winn assay with antitumor immune lymphoid cells was shown to be tumor specific and mediated by Thy 1+ cells. Mouse chimeras were constructed by injecting fetal liver cells into irradiated recipients. BALB\/c \u2192 (BALB\/c \u00d7 C3Hf)F1 and control (BALB\/c \u00d7 C3Hf)F1 \u2192 (BALB\/c \u00d7 C3Hf)F1 chimeras were unable to develop a transplantation immunity against the immunizing tumor, whereas (BALB\/c \u00d7 C3Hf)F1 \u2192 BALB\/c chimeras were able to respond to the immunizing tumor. Thus, unresponsiveness was shown to be due to a defect in the maturation of precursor stem cells both of parental and F1 hybrid origin in the body of the (BALB\/c \u00d7 C3Hf)F1 animals.\n                  <\/jats:p>","DOI":"10.1177\/030089168507100201","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:41:34Z","timestamp":1523943694000},"page":"91-96","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Unresponsiveness to a Murine Fibrosarcoma Determined by the Host Genetic Environment but not by Lymphocyte Precursor Genotype"],"prefix":"10.1177","volume":"71","author":[{"given":"Mario P.","family":"Colombo","sequence":"first","affiliation":[{"name":"Division of Experimental Oncology D, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Rodolfo","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology D, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Parmiani","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology D, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1985,4,1]]},"reference":[{"key":"bibr1-030089168507100201","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1978.tb00385.x"},{"key":"bibr2-030089168507100201","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1978.65"},{"key":"bibr3-030089168507100201","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910310414"},{"key":"bibr4-030089168507100201","first-page":"277","volume":"31","author":"Clark E.A.","year":"1980","journal-title":"Adv. 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