{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:10:27Z","timestamp":1777918227175,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1985,4,1]],"date-time":"1985-04-01T00:00:00Z","timestamp":481161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1985,4]]},"abstract":"<jats:p>A rare case of a one-year-old child with Wilms\u2019 tumor, aniridia and glaucoma is described, in whom bone marrow chromosome analysis showed the presence of an interstitial micro-deletion on the short arm of chromosome 11, presumably involving the pl3 band. Research of the enzyme activity of RBC catalase showed a 40% reduction. This finding is compatible with the loss of the 11p13 band which contains the gene coding this enzyme. 11p13 deletion in Wilms\u2019 tumor and 13q interstitial deletion in retinoblastoma provide a rare case of pre-zygotic chromosome abnormality, which may be considered to have a determinant role in the tumor etiopathogenesis.<\/jats:p>","DOI":"10.1177\/030089168507100205","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:41:34Z","timestamp":1523943694000},"page":"119-121","source":"Crossref","is-referenced-by-count":7,"title":["11p13 Deletion and Reduced RBC Catalase in a Patient with Aniridia, Glaucoma and Bilateral Wilms\u2019 Tumor"],"prefix":"10.1177","volume":"71","author":[{"given":"Cosimo","family":"Barletta","sequence":"first","affiliation":[{"name":"Dipartimento di Genetica e Microbiologia, Universit\u00e0 degli Studi di Pavia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel Adolfo","family":"Castello","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Pediatrica, Universit\u00e0 \u00ab La Sapienza \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Pediatrica, Universit\u00e0 \u00ab La Sapienza \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Mavelli","sequence":"additional","affiliation":[{"name":"Istituto di Biochimica Applicata, Universit\u00e0 \u00ab La Sapienza \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Clerico","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Pediatrica, Universit\u00e0 \u00ab La Sapienza \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rosa","family":"Ciriolo","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia, Universit\u00e0 \u00ab Tor Vergata \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Vignetti","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Pediatrica, Universit\u00e0 \u00ab La Sapienza \u00bb, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1985,4,1]]},"reference":[{"key":"bibr1-030089168507100205","doi-asserted-by":"publisher","DOI":"10.1038\/309176a0"},{"key":"bibr2-030089168507100205","first-page":"81A","volume":"30","author":"Francke U.","year":"1978","journal-title":"Am. 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