{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:10:48Z","timestamp":1777918248130,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1985,12,1]],"date-time":"1985-12-01T00:00:00Z","timestamp":502243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1985,12]]},"abstract":"<jats:p>5\u2032Nucleotidase (EC 3.1.3.5), a purine pathway enzyme, occurs as a cellular ectoenzyme. Widely differing 5\u2032N activity has been reported in different types of lymphoid cells and appears to be related to lymphocyte function, differentiation and immunological subtype. This paper reports a study on the ultrastructural distribution of 5\u2032N in different types of lymphoid leukemias and non-Hodgkin's lymphomas. In lymphoid leukemias, only cALL cells showed strong 5\u2032N staining. In CLL, PLL and HCL the intensity of staining was less than in normal cells. In the NHL group, the reaction pattern was mixed. Infiltrating neoplastic cells, specially the large lymphoid cells, consistently showed very mild activity of the enzyme, whereas follicular center cells and other mature lymphocytes were characterized by moderately strong to strong 5\u2032N activity. These results support the view that 5\u2032N is a marker of lymphocyte cell differentiation.<\/jats:p>","DOI":"10.1177\/030089168507100604","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:25:23Z","timestamp":1523881523000},"page":"537-542","source":"Crossref","is-referenced-by-count":1,"title":["Ultrastructural Localization of 5\u2032nucleotidase in Human Normal and Malignant Lymphoid Cells"],"prefix":"10.1177","volume":"71","author":[{"given":"Sulochana R.","family":"Gawande","sequence":"first","affiliation":[{"name":"Cancer Research Institute and Tata Memorial Hospital, Parel, Bombay, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Gopal","sequence":"additional","affiliation":[{"name":"Cancer Research Institute and Tata Memorial Hospital, Parel, Bombay, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh H.","family":"Advani","sequence":"additional","affiliation":[{"name":"Cancer Research Institute and Tata Memorial Hospital, Parel, Bombay, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satyavati M.","family":"Sirsat","sequence":"additional","affiliation":[{"name":"Cancer Research Institute and Tata Memorial Hospital, Parel, Bombay, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1985,12,1]]},"reference":[{"key":"bibr1-030089168507100604","doi-asserted-by":"publisher","DOI":"10.1038\/261239a0"},{"key":"bibr2-030089168507100604","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03563.x"},{"key":"bibr3-030089168507100604","unstructured":"BessisM.: Living Blood Cells and Their Ultrastructure. 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