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The risk of developing lymph node metastases was fourfold in tumors with a diameter greater than 2 cm when compared to those with a diameter less than or equal to 2 cm. The most commonly metastasized lymph node level, in both large and small tumors, was the first; however, one-fifth of the patients had simultaneous lymph node metastasis in all three axillary levels. Although the left breast was the most affected (58.9 %), there was no evidence of a different risk of metastasis between the two breasts; 34.1 % of the tumors were multifocal. Lymph node involvement was higher in women under 50 years of age with a primary tumor larger than 2 cm.<\/jats:p>","DOI":"10.1177\/030089168607200306","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T05:51:17Z","timestamp":1539669077000},"page":"259-265","source":"Crossref","is-referenced-by-count":6,"title":["Primary Tumor Site, Size, Patients Age and Axillary Lymph Nodes in Breast Cancers"],"prefix":"10.1177","volume":"72","author":[{"given":"Salvatore","family":"Toma","sequence":"first","affiliation":[{"name":"Department of Clinical Oncology, Istituto di Oncologia, Universit\u00e0 di Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Bonassi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Puntoni","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Nicol\u00f2","sequence":"additional","affiliation":[{"name":"Department of Pathology, Istituto Nazionale per la Ricerca sul Cancro, Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,6,1]]},"reference":[{"key":"bibr1-030089168607200306","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197301000-00002"},{"key":"bibr2-030089168607200306","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820701)50:1<18::AID-CNCR2820500105>3.0.CO;2-J"},{"key":"bibr3-030089168607200306","first-page":"28","volume":"90","author":"Egan R.L.","year":"1984","journal-title":"Cancer Res."},{"key":"bibr4-030089168607200306","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196911)24:5<1071::AID-CNCR2820240533>3.0.CO;2-H"},{"key":"bibr5-030089168607200306","first-page":"79","volume":"131","author":"Fisher B.","year":"1970","journal-title":"Surg. 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