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We describe two cases of hepatocellular carcinoma: one was entirely composed of spindle-shaped cells, and the other was a typical hepatocellular carcinoma with only a small area of sarcomatous, fusiform cells. In the first case, ultrastructural studies demonstrated desmosomes and many Mallory bodies and confirmed the epithelial nature of the neoplasm. In the second case, no ultrastructural studies were available, but the presence of gradual transition from liver cell carcinoma to spindle-cell carcinoma excludede the diagnosis of carcino-sarcoma.<\/jats:p>","DOI":"10.1177\/030089168707300219","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:15:59Z","timestamp":1523880959000},"page":"195-201","source":"Crossref","is-referenced-by-count":6,"title":["A Light Microscopic and Ultrastructural Study of Spindle-Shaped Hepatocellular Carcinoma"],"prefix":"10.1177","volume":"73","author":[{"given":"Salvatore","family":"Andreola","sequence":"first","affiliation":[{"name":"Divisioni di Anatomia Patologica e Citologia, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo A.","family":"Audisio","sequence":"additional","affiliation":[{"name":"Oncologia Chirurgica A, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Oncologia Sperimentale A, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1987,4,1]]},"reference":[{"key":"bibr1-030089168707300219","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90588-8"},{"key":"bibr2-030089168707300219","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197508)36:2<446::AID-CNCR2820360220>3.0.CO;2-7"},{"key":"bibr3-030089168707300219","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830415)51:8<1510::AID-CNCR2820510826>3.0.CO;2-K"},{"key":"bibr4-030089168707300219","first-page":"584","volume":"46","author":"Denk H.","year":"1982","journal-title":"Lab. 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