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Leukopenia was severe in all patients, who additionally experienced hypokalemia with excessive kaliuresis. The etiology of the observed hypokalemia is unclear. We suspect that vinblastine may induce renal tubular dysfunction. These toxicities appear dose-related.<\/jats:p>","DOI":"10.1177\/030089168707300515","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:36:10Z","timestamp":1523943370000},"page":"513-516","source":"Crossref","is-referenced-by-count":10,"title":["Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Hepatic Arterial Infusion of Vinblastine in Three Patients with Breast Cancer"],"prefix":"10.1177","volume":"73","author":[{"given":"Giuseppe","family":"Fraschini","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Breast Section, The University of Texas, M.D. Anderson Hospital and Tumor Institute Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Recchia","sequence":"additional","affiliation":[{"name":"Divisione di Medicina, Servizio Oncologia, Ospedale Civile, Avezzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frankie A.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Breast Section, The University of Texas, M.D. Anderson Hospital and Tumor Institute Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1987,10,1]]},"reference":[{"key":"bibr1-030089168707300515","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)56132-7"},{"key":"bibr2-030089168707300515","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(67)90096-4"},{"key":"bibr3-030089168707300515","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(71)90244-0"},{"key":"bibr4-030089168707300515","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850715)56:2<225::AID-CNCR2820560203>3.0.CO;2-Y"},{"key":"bibr5-030089168707300515","first-page":"313","volume":"71","author":"Fraschini G.","year":"1987","journal-title":"Cancer Treat. 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