{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:12:59Z","timestamp":1777918379168,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1989,6,1]],"date-time":"1989-06-01T00:00:00Z","timestamp":612662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1989,6]]},"abstract":"<jats:p>\n                    From January 1985 to December 1987, 17 patients with advanced malignant melanoma were treated with the poly-chemotherapy regimen BELD (bleomycin, 15 mg subcutaneously on day 1 and 4, vindesine 3 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    intravenously on day 1 and 5, CCNU 80 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    orally on day 1 and DTIC 200 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    intravenously on day 1 through 5) proposed as effective (CR + PR 45%) and tolerable. All patients were evaluable for toxicity and 14\/17 also for response after 2 BELD cycles (total n. of cycles was 54). Criteria for response were just the same as those used by Young et al. A complete remission and a partial remission (2\/14) have been observed at lymph nodal level, the unique sites of the disease in these two patients. Remission lasted 6 and 4 months, respectively. Two other patients showed a minimal response of 2 and 3 months duration (lymphonodal and cutis, respectively); 9 patients had stabilized disease of 5 months median duration. One case of progression of disease was observed. However, toxicity was relevant because of 2 early deaths after the first cycle, most probably therapy related; nausea and vomiting (82%), leukopenia (17%) and muscle rigors (11%).\n                  <\/jats:p>","DOI":"10.1177\/030089168907500308","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T11:15:39Z","timestamp":1524482139000},"page":"229-232","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness and Toxicity of \u00abBeld\u00bb Polychemotherapy in Advanced Malignant Melanoma"],"prefix":"10.1177","volume":"75","author":[{"given":"Giuseppe","family":"Cartei","sequence":"first","affiliation":[{"name":"Divisione di Oncologia Medica, Ospedale Civile, Udine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tino","family":"Ceschia","sequence":"additional","affiliation":[{"name":"Divisione di Oncologia Medica, Ospedale Civile, Udine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Marsilio","sequence":"additional","affiliation":[{"name":"Divisione di Oncologia Medica, Ospedale Civile, Udine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Clocchiatti","sequence":"additional","affiliation":[{"name":"Divisione di Oncologia Medica, Ospedale Civile, Udine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpiero","family":"Fasola","sequence":"additional","affiliation":[{"name":"Divisione di Oncologia Medica, Ospedale Civile, Udine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Morandini","sequence":"additional","affiliation":[{"name":"Divisione di Oncologia Medica, Ospedale Civile, Udine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Galletti","sequence":"additional","affiliation":[{"name":"Divisione di Oncologia Medica, Ospedale Civile, Udine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Sibau","sequence":"additional","affiliation":[{"name":"Divisione di Oncologia Medica, Ospedale Civile, Udine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1989,6,1]]},"reference":[{"key":"bibr1-030089168907500308","first-page":"411","volume-title":"Manuale di Oncologia Medica","author":"Bonadonna G.","year":"1987","edition":"3"},{"key":"bibr2-030089168907500308","first-page":"1988","volume":"61","author":"Ceci G.","year":"1988","journal-title":"Is it really a rare event? Cancer"},{"key":"bibr3-030089168907500308","volume-title":"Protocollo di diagnosi e terapia.","author":"Forza Operativa Nazionale sul Melanoma Cutaneo.","year":"1987"},{"key":"bibr4-030089168907500308","first-page":"13","volume":"8","author":"Lissoni P.","year":"1987","journal-title":"Argomenti di Oncologia"},{"key":"bibr5-030089168907500308","first-page":"1384","volume-title":"Cancer Principles and Practice of Oncology.","author":"Mastrangelo M.J.","year":"1985","edition":"2"},{"key":"bibr6-030089168907500308","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6"},{"key":"bibr7-030089168907500308","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810915)48:6<1290::AID-CNCR2820480605>3.0.CO;2-1"},{"key":"bibr8-030089168907500308","first-page":"877","volume":"71","author":"Dratz R.","year":"1987","journal-title":"Cancer Treat. Rep."},{"key":"bibr9-030089168907500308","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19801201)46:11<2346::AID-CNCR2820461104>3.0.CO;2-6"},{"key":"bibr10-030089168907500308","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860415)57:8+<1675::AID-CNCR2820571307>3.0.CO;2-I"},{"key":"bibr11-030089168907500308","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197407112910205"},{"key":"bibr12-030089168907500308","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850501)55:9<1879::AID-CNCR2820550906>3.0.CO;2-1"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089168907500308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089168907500308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:37:37Z","timestamp":1777660657000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089168907500308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,6]]}},"alternative-id":["10.1177\/030089168907500308"],"URL":"https:\/\/doi.org\/10.1177\/030089168907500308","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,6]]}}}