{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:13:15Z","timestamp":1777918395491,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1989,10,1]],"date-time":"1989-10-01T00:00:00Z","timestamp":623203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:p>\n                    The use of more aggressive chemotherapies in the treatment of patients with some tumors has caused a higher frequency of neutropenia and subsequent serious infections. To verify the role in these patients of a combination therapy of amikacin (300 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    i.v. every 12 hours) plus ceftazidime (2 g\/m\n                    <jats:sup>2<\/jats:sup>\n                    i.v. every 8 hours) adminsitered as initial empiric treatment, followed in non-responsive cases by a second-line therapy with clindamycin (300 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    i.v. every 8 hours), we conducted a prospective study in 45 febrile episodes (temperature \u226538.5 \u00b0C) in neutropenic patients (neutrophils \u2264500\/ml). The patients' median age was 58 (range, 19-80); 29 were women and 16 were men. The median performance status was 50 (range, 30-90), and 71 % of the patients had progressive tumoral disease. Before antibiotic therapy the median duration of fever was 12 hours (range, 4-48 hours). The median granulocyte count was 350\/ml (range, 100-500 cells\/ml), and the median peak temperature was 38.8 \u00b0C (range, 38.5-41 \u00b0C). The median time for neutrophils to rise towards 1000\/ml was 4 days (range, 2-12), and the median duration of therapy was 8 days (range, 3-12). Documented bacterial infections were present in 28 patients whereas 17 had clinically possible infections or fever of unknown origin. The infection sites in microbiologically documented infections were: septicemia (12), multiple sites (4), tonsillitis (4), urinary tract (4), pneumonia (2) and fistula (2). Complete response to first-line therapy was obtained in 36 out of 45 episodes (80 %; 95 % confidence limits from 65 % to 90 %). Five out of 8 cases responded to second-line therapy with clindamycin for an overall recovery rate of 91 %. The amikacin-ceftazidime combination followed by clindamycin in non-responsive cases is effective, with moderate toxicity in non-leukemic febrile neutropenic patients.\n                  <\/jats:p>","DOI":"10.1177\/030089168907500508","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:35:23Z","timestamp":1523943323000},"page":"443-448","source":"Crossref","is-referenced-by-count":0,"title":["Combination Antibiotic Treatment of Chemotherapy-Induced Neutropenia in Non-Leukemic Patients"],"prefix":"10.1177","volume":"75","author":[{"given":"Giampietro","family":"Gasparini","sequence":"first","affiliation":[{"name":"Centro di Riferimento Oncologico, Aviano, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Turnolo","sequence":"additional","affiliation":[{"name":"Centro di Riferimento Oncologico, Aviano, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Toffoli","sequence":"additional","affiliation":[{"name":"Centro di Riferimento Oncologico, Aviano, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Talamini","sequence":"additional","affiliation":[{"name":"Centro di Riferimento Oncologico, Aviano, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Vaglia","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, St. Bortolo Hospital, Vicenza, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Benedetti","sequence":"additional","affiliation":[{"name":"Medical Division, Glaxo S.p.A., Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1989,10,1]]},"reference":[{"key":"bibr1-030089168907500508","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90140-4"},{"key":"bibr2-030089168907500508","first-page":"576","volume":"69","author":"Bajetta E.","year":"1984","journal-title":"Haematologica"},{"key":"bibr3-030089168907500508","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-95-5-549"},{"key":"bibr4-030089168907500508","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197408)34:2<431::AID-CNCR2820340229>3.0.CO;2-9"},{"key":"bibr5-030089168907500508","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(75)80005-3"},{"key":"bibr6-030089168907500508","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-64-2-328"},{"key":"bibr7-030089168907500508","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870715)60:2<255::AID-CNCR2820600224>3.0.CO;2-L"},{"key":"bibr8-030089168907500508","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90476-6"},{"key":"bibr9-030089168907500508","volume-title":"Amikacin short or full course plus ceftazidime versus amikacin plus azlocillin for gram-negative bacteremia in granulocytopenic cancer patients.","author":"E.O.R.T.C. Antimicrobial Therapy Project Group","year":"1986"},{"key":"bibr10-030089168907500508","first-page":"348","volume":"2","author":"Esparza L.","year":"1983","journal-title":"Proc. Am. Soc. Clin. Oncol."},{"key":"bibr11-030089168907500508","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.26.3.378"},{"key":"bibr12-030089168907500508","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197402)33:2<568::AID-CNCR2820330236>3.0.CO;2-2"},{"key":"bibr13-030089168907500508","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.5.703"},{"key":"bibr14-030089168907500508","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90258-5"},{"key":"bibr15-030089168907500508","first-page":"1433","volume":"61","author":"Klastersky J.","year":"1977","journal-title":"Cancer Treat. 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