{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:13:18Z","timestamp":1777918398809,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1989,12,1]],"date-time":"1989-12-01T00:00:00Z","timestamp":628473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1989,12]]},"abstract":"<jats:p>In a patient with long untreated slow-growing osteoblastic bone metastases from an ER\/PgR negative breast carcinoma, new metastatic sites in many lymphnodes pleura and massively in liver have been observed 4 weeks after receiving tamoxifen. Cause-effect relationship between administration of the drug and this unusually rapid spreading of the disease may be considered only as a hypothesis, as it is based wholly on clinical outcome. However, reporting of any exacerbation of breast cancer apparently induced by tamoxifen, even if only anecdotal, is advisable.<\/jats:p>","DOI":"10.1177\/030089168907500610","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T11:15:10Z","timestamp":1524482110000},"page":"566-569","source":"Crossref","is-referenced-by-count":1,"title":["Exacerbation of Metastatic Disease Shortly after Administration of Tamoxifen in ER Negative Advanced Breast Carcinoma. A Case Report"],"prefix":"10.1177","volume":"75","author":[{"given":"Giorgio","family":"Cocconi","sequence":"first","affiliation":[{"name":"(Medical Oncology Service, Ospedale Maggiore, Parma)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Boni","sequence":"additional","affiliation":[{"name":"(Medical Oncology Service, Ospedale Maggiore, Parma)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Naldi","sequence":"additional","affiliation":[{"name":"(Medical Oncology Service, Ospedale Maggiore, Parma)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Nizzoli","sequence":"additional","affiliation":[{"name":"(Medical Oncology Service, Ospedale Maggiore, Parma)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Bozzetti","sequence":"additional","affiliation":[{"name":"(Medical Oncology Service, Ospedale Maggiore, Parma)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1989,12,1]]},"reference":[{"key":"bibr1-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1981.00340090136038"},{"key":"bibr2-030089168907500610","author":"Baum M.","year":"1988","journal-title":"The role of endocrine therapy in primary breast cancer."},{"key":"bibr3-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1177\/030089168607200511"},{"key":"bibr4-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1985.3.2.222"},{"key":"bibr5-030089168907500610","first-page":"2178","volume-title":"Drug and Hormone Resistance in Neoplasm.","author":"Bruchovsky N.","year":"1983"},{"key":"bibr6-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1007\/BF00258204"},{"key":"bibr7-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198607243150417"},{"key":"bibr8-030089168907500610","author":"Cocconi G.","journal-title":"Am. J. Clin. Oncol."},{"key":"bibr9-030089168907500610","first-page":"5926","volume":"45","author":"Conte P.F.","year":"1985","journal-title":"Cancer Res.,"},{"key":"bibr10-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1177\/030089167706300507"},{"key":"bibr11-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6072.1351-e"},{"key":"bibr12-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198107023050101"},{"key":"bibr13-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1983.1.4.227"},{"key":"bibr14-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)54531-0"},{"key":"bibr15-030089168907500610","first-page":"55","volume":"1","author":"Goldhirsch A.","year":"1986","journal-title":"NCI monographs,"},{"key":"bibr16-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0130101"},{"key":"bibr17-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930340311"},{"key":"bibr18-030089168907500610","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-197816010-00001"},{"key":"bibr19-030089168907500610","first-page":"231","volume":"5","author":"Katzenellenbogen B.S.","year":"1985","journal-title":"Treat.,"},{"key":"bibr20-030089168907500610","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-87-6-687"},{"key":"bibr21-030089168907500610","first-page":"1839","volume":"63","author":"Lagault-Poisson S.","year":"1979","journal-title":"Cancer Treat. Rep.,"},{"key":"bibr22-030089168907500610","first-page":"1431","volume":"60","author":"Lerner H.J.","year":"1976","journal-title":"Cancer Treat. Rep.,"},{"key":"bibr23-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1007\/BF01806790"},{"key":"bibr24-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800641218"},{"key":"bibr25-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1159\/000225860"},{"key":"bibr26-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)91127-3"},{"key":"bibr27-030089168907500610","first-page":"1437","volume":"60","author":"Morgan L.R.","year":"1976","journal-title":"Cancer Treat. Rep.,"},{"key":"bibr28-030089168907500610","first-page":"115","volume":"1","author":"Mouridsen H.T.","year":"1986","journal-title":"NCI monographs,"},{"key":"bibr29-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(78)80017-6"},{"key":"bibr30-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811215)48:12<2674::AID-CNCR2820481220>3.0.CO;2-N"},{"key":"bibr31-030089168907500610","first-page":"1","volume":"1","author":"NIH Consensus Development Conference on Adjuvant Chemotherapy and Endocrine Therapy for Breast Cancer.","year":"1986","journal-title":"Proceed of the NIH Consensus Development Conference on Adjuvant Chemotherapy and Endocrine Therapy for Breast Cancer."},{"key":"bibr32-030089168907500610","first-page":"584","volume":"45","author":"Osborne C.K.","year":"1985","journal-title":"Cancer Res.,"},{"key":"bibr33-030089168907500610","first-page":"563","volume":"9","author":"Patterson J.S.","year":"1982","journal-title":"Rev. Endocrine Related Cancer, suppl."},{"key":"bibr34-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90053-3"},{"key":"bibr35-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1978.03290240044022"},{"key":"bibr36-030089168907500610","first-page":"61","volume":"6","author":"Pritchard K.I.","year":"1987","journal-title":"Proceed ASCO,"},{"key":"bibr37-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(84)90062-2"},{"key":"bibr38-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91385-6"},{"key":"bibr39-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19851015)56:8<1982::AID-CNCR2820560816>3.0.CO;2-I"},{"key":"bibr40-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-81406-8_22"},{"key":"bibr41-030089168907500610","first-page":"75","volume":"1","author":"Tormey D.C.","year":"1986","journal-title":"NCI monographs,"},{"key":"bibr42-030089168907500610","first-page":"1451","volume":"60","author":"Tormey D.C.","year":"1976","journal-title":"Cancer Treat. Rep.,"},{"key":"bibr43-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6201.1329"},{"key":"bibr44-030089168907500610","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870915)60:6<1163::AID-CNCR2820600602>3.0.CO;2-D"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089168907500610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089168907500610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:38:07Z","timestamp":1777660687000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089168907500610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,12]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1989,12]]}},"alternative-id":["10.1177\/030089168907500610"],"URL":"https:\/\/doi.org\/10.1177\/030089168907500610","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,12]]}}}