{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:13:27Z","timestamp":1777918407915,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1990,2,1]],"date-time":"1990-02-01T00:00:00Z","timestamp":633830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:p>\n                    Thirty-two patients with advanced non-small cell lung cancer (NSCLC) were entered in this study to evaluate the efficacy and toxicity of a chemotherapy schedule including cisplatin (C) 40 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    intravenously (i.v.) on days 1\u20133; vindesine (V) 3 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    i.v. on day 1, and cytarabine (ara-C) 15 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    subcutaneously every 12 hours on days 1\u20133 (total dose: 90 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ). Cisplatin was administered simultaneously with one dose of ara-C. Cycles were repeated every 28 days. Five patients out of 28 (18 %) fully evaluable for response presented partial remissions. No complete response was observed. Median survival was 8 months and median duration of response was 4 months. Hematologic toxicity was severe in 3 patients. There were no toxicity-related deaths. Other adverse reactions included nausea and vomiting, alopecia and peripheral neuropathy. We conclude that this chemotherapy combination is marginally effective against NSCLC showing in this group of patients a low number of responses of short duration without a significant impact on survival.\n                  <\/jats:p>","DOI":"10.1177\/030089169007600109","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:25:41Z","timestamp":1523942741000},"page":"35-37","source":"Crossref","is-referenced-by-count":0,"title":["Phase II Trial of Cytarabine, Cisplatin and Vindesine for Advanced Non-Small Cell Lung Cancer"],"prefix":"10.1177","volume":"76","author":[{"given":"Adrian","family":"Bianco","sequence":"first","affiliation":[{"name":"Instituto de Hematolog\u00eda y Oncologia, Mar Del Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan E.","family":"Perez","sequence":"additional","affiliation":[{"name":"Hospital J.M. Penna, Bahia Bianca Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Machiavelli","sequence":"additional","affiliation":[{"name":"Hospital Leonidas Lucero, Bah\u00eda Bianca Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo A.","family":"Leone","sequence":"additional","affiliation":[{"name":"Hospital Provincial Neuqu\u00e9n, Neuqu\u00e9n Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Romero","sequence":"additional","affiliation":[{"name":"Hospital Italiano Regional del Sur, Bah\u00eda Bianca Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario G.","family":"Rabinovich","sequence":"additional","affiliation":[{"name":"Hospital Provincial Neuqu\u00e9n, Neuqu\u00e9n Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos T.","family":"Vallejo","sequence":"additional","affiliation":[{"name":"Hospital Provincial Neuqu\u00e9n, Neuqu\u00e9n Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Instituto de Hematolog\u00eda y Oncologia, Mar Del Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Cuevas","sequence":"additional","affiliation":[{"name":"Hospital Leonidas Lucero, Bah\u00eda Bianca Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Universidad Nacional Del Comahue, Neuqu\u00e9n. Grupo Oncol\u00f3gico Cooperativo del Sur (G.O.C.S.), Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1990,2,1]]},"reference":[{"key":"bibr1-030089169007600109","first-page":"25","volume":"41","author":"Bergerat J.P.","year":"1981","journal-title":"Cancer Res."},{"key":"bibr2-030089169007600109","first-page":"89","volume":"13","author":"Bonomi P.","year":"1986","journal-title":"Semin. Oncol. (suppl.)"},{"key":"bibr3-030089169007600109","first-page":"753","volume":"7","author":"Dillman R.O.","year":"1988","journal-title":"Proc. Am. Soc. Clin. Oncol."},{"key":"bibr4-030089169007600109","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(85)80116-2"},{"key":"bibr5-030089169007600109","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-95-4-414"},{"key":"bibr6-030089169007600109","doi-asserted-by":"publisher","DOI":"10.1378\/chest.89.4_Supplement.295S"},{"key":"bibr7-030089169007600109","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"bibr8-030089169007600109","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6"},{"key":"bibr9-030089169007600109","first-page":"121","volume":"13","author":"Osoba D.","year":"1986","journal-title":"Semin. Oncol. 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Rep."},{"key":"bibr13-030089169007600109","first-page":"1105","volume":"46","author":"Vadi H.","year":"1986","journal-title":"Cancer Res."}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169007600109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169007600109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:38:21Z","timestamp":1777660701000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089169007600109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,2]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,2]]}},"alternative-id":["10.1177\/030089169007600109"],"URL":"https:\/\/doi.org\/10.1177\/030089169007600109","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,2]]}}}