{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:14:07Z","timestamp":1777918447676,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1990,12,1]],"date-time":"1990-12-01T00:00:00Z","timestamp":660009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1990,12]]},"abstract":"<jats:p>\n                    Using two different agar based double-layer culture assays, 16 bilharzial urinary bladder carcinoma samples were evaluated for the in-vitro effects of 1 hour's exposure to \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    interferon at 3-log concentrations. Ten of these tumor samples were evaluable for drug sensitivity testing. In the liquid top layer dye exclusion assay, 40%, 60%, and 60% of the 10 tested tumor samples were sensitive to \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    interferon 100, 1,000, and 10,000 units\/ml respectively, and 25%, 25%, and 63% of 8 tumor cell suspensions were sensitive to the above drug concentrations when the human tumor colony forming assay was performed. Comparing both assays in 24 different drug measurements, there was a 71% concordance rate. All of the 7 discordant measurements were sensitive in the dye exclusion and resistant in the clonogenic assays. Thus, bilharzial bladder cancer cells are relatively sensitive to the in-vitro effect of \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    interferon, especially ot higher concentrations, and a phase II clinical trial deserves consideration.\n                  <\/jats:p>","DOI":"10.1177\/030089169007600615","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:33:24Z","timestamp":1523943204000},"page":"582-584","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of In-Vitro Effects of Recombinant Human \u03b1\n                    <sub>2<\/sub>\n                    Interferon on Bilharzial Urinary Bladder Cancer Cells"],"prefix":"10.1177","volume":"76","author":[{"given":"Hussein M.","family":"Khaled","sequence":"first","affiliation":[{"name":"Medical Oncology Department and Virology and Immunology Unit, National Cancer Institute, Cairo University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed M.","family":"Attia","sequence":"additional","affiliation":[{"name":"Medical Oncology Department and Virology and Immunology Unit, National Cancer Institute, Cairo University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel-Rahman","family":"Nabawi","sequence":"additional","affiliation":[{"name":"Medical Oncology Department and Virology and Immunology Unit, National Cancer Institute, Cairo University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1990,12,1]]},"reference":[{"issue":"2","key":"bibr1-030089169007600615","first-page":"48","volume":"14","author":"Bonnem E.M.","year":"1987","journal-title":"Semin. Oncol."},{"key":"bibr2-030089169007600615","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19841201)54:2+<2770::AID-CNCR2820541425>3.0.CO;2-0"},{"key":"bibr3-030089169007600615","first-page":"163","volume-title":"In: Bladder cancer","author":"El-Sebai I.","year":"1983"},{"key":"bibr4-030089169007600615","first-page":"211","author":"Gad El-Mawla N.","year":"1987","journal-title":"Chemothera-peutic management of invasive bladder cancer: Ten years experience"},{"key":"bibr5-030089169007600615","first-page":"3438","volume":"38","author":"Hamburger A.W.","year":"1979","journal-title":"Cancer Res."},{"key":"bibr6-030089169007600615","first-page":"1","volume":"3","author":"Ibrahim A.S.","year":"1984","journal-title":"J. Egypt. Natl. Cancer Inst., 1"},{"key":"bibr7-030089169007600615","first-page":"293","volume":"4","author":"Khaled H.M.","year":"1983","journal-title":"Int. J. Cell Cloning., 1"},{"key":"bibr8-030089169007600615","author":"Khaled H.M.","journal-title":"J. Egypt, Natl. Inst."},{"key":"bibr9-030089169007600615","first-page":"207","volume":"2","author":"Krown S.E.","year":"1986","journal-title":"Semin. Oncol., 13"},{"key":"bibr10-030089169007600615","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1983.1.3.217"},{"key":"bibr11-030089169007600615","doi-asserted-by":"publisher","DOI":"10.1007\/BF00256974"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169007600615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169007600615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:39:04Z","timestamp":1777660744000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089169007600615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1990,12]]}},"alternative-id":["10.1177\/030089169007600615"],"URL":"https:\/\/doi.org\/10.1177\/030089169007600615","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,12]]}}}