{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:14:12Z","timestamp":1777918452041,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1991,4,1]],"date-time":"1991-04-01T00:00:00Z","timestamp":670464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1991,4]]},"abstract":"<jats:p>\n                    Thirty previously untreated patients with advanced measurable gastric cancer were given a combination chemotherapy consisting of 5-fluorouracil, 400 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , and leucovorin, 200 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    iv on days 1 to 3, mitomicyn-C, 10 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    on day 1 (every other cycle) and adriamycin, 40 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    on day 2, repeated every 21 days. The overall response rate was 46 % (14\/30; 95 % confidence limits: 28 %-64 %) including 4 patients with a complete remission. Eight patients progressed. Median duration of remission (CR+PR) was 10 months, with a median survival of 13, 8 and 4 months for CR + PR, NC and PD, respectively. Main toxicities were leukopenia (WHO grade III-IV in 36 % of the patients) and alopecia. One patient died from myocardial infarction after an adriamycin cumulative dose of 480 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    . No other treatment-related death occurred. L-FAM\n                    <jats:sub>2<\/jats:sub>\n                    is an effective combination for advanced gastric carcinoma. Further studies based on the association of leucovorin and 5-fluorouracil in combination with other active drugs are warranted.\n                  <\/jats:p>","DOI":"10.1177\/030089169107700214","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:46:26Z","timestamp":1523943986000},"page":"160-163","source":"Crossref","is-referenced-by-count":2,"title":["Mitomycin-c, Adriamycin, 5-Fluorouracil and Leucovorin (L-FAM\n                    <sub>2<\/sub>\n                    ) in the Treatment of Advanced Gastric Cancer: A Phase II Study"],"prefix":"10.1177","volume":"77","author":[{"given":"Alberto","family":"Zaniboni","sequence":"first","affiliation":[{"name":"III Divisione di Medicina Generale, Servizio Oncologia, Spedali Civili, Brescia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edda","family":"Simoncini","sequence":"additional","affiliation":[{"name":"III Divisione di Medicina Generale, Servizio Oncologia, Spedali Civili, Brescia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Marpicatl","sequence":"additional","affiliation":[{"name":"III Divisione di Medicina Generale, Servizio Oncologia, Spedali Civili, Brescia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto","family":"Meriggi","sequence":"additional","affiliation":[{"name":"III Divisione di Medicina Generale, Servizio Oncologia, Spedali Civili, Brescia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Arcangeli","sequence":"additional","affiliation":[{"name":"III Divisione di Medicina Generale, Servizio Oncologia, Spedali Civili, Brescia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Garattini","sequence":"additional","affiliation":[{"name":"Divisione di Chirurgia, Gardone VT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Raffaglio","sequence":"additional","affiliation":[{"name":"Divisione di Chirurgia, Gardone VT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelio","family":"Ferragni","sequence":"additional","affiliation":[{"name":"I Medicina, Istituti Ospitalieri, Cremona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Marini","sequence":"additional","affiliation":[{"name":"III Divisione di Medicina Generale, Servizio Oncologia, Spedali Civili, Brescia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,4,1]]},"reference":[{"key":"bibr1-030089169107700214","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890315)63:6+<1036::AID-CNCR2820631309>3.0.CO;2-K"},{"key":"bibr2-030089169107700214","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.8.1150"},{"key":"bibr3-030089169107700214","first-page":"104","volume":"8","author":"Arbuk S.G.","year":"1989","journal-title":"Proc. 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