{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:14:14Z","timestamp":1777918454216,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1991,6,1]],"date-time":"1991-06-01T00:00:00Z","timestamp":675734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:p>Eight pesticides were tested in a bioassay based on the induction of preneoplastic lesions in the liver. Rats were given diethylnitrosamine intraperitoneally at 200 mg\/kg bw and two weeks later were treated with pesticides for six weeks and then killed; all rats had a partial hepatectomy at week 3. Hepatocarcinogenic potential was assessed by comparing the number and area of glutathione s-transferase (placental form) -positive foci In the liver with those of controls given diethylnitrosamine alone. Positive results were seen with Chinomethionat, Phosmet and Propiconazole; the results obtained with Captan and Prochloraz were borderline; Benomyl, Daminozide and Folpet gave negative results. Our findings provide enough experimental evidence to indicate that great care should be exercised in the use of these compounds.<\/jats:p>","DOI":"10.1177\/030089169107700301","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T11:10:41Z","timestamp":1524481841000},"page":"185-188","source":"Crossref","is-referenced-by-count":16,"title":["A Rapid in vivo Bioassay for the Carcinogenicity of Pesticides"],"prefix":"10.1177","volume":"77","author":[{"given":"Ricardo","family":"Cabral","sequence":"first","affiliation":[{"name":"First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Hoshiya","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Hakoi","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Fukushima","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Ito","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,6,1]]},"reference":[{"key":"bibr1-030089169107700301","doi-asserted-by":"publisher","DOI":"10.1177\/096032718800700502"},{"key":"bibr2-030089169107700301","volume-title":"Pesticide residues in food (Captan) 1965\/69\/73\/77\/78\/82 and 84 evaluations.","author":"FAO\/WHO:"},{"key":"bibr3-030089169107700301","volume-title":"Pesticide residues in food (Folpet) 1969\/73\/82\/84 and 86 evaluations.","author":"FAO\/WHO:"},{"key":"bibr4-030089169107700301","volume-title":"Pesticide residues in food (Phosmet) 1978 and 1979 evaluations.","author":"FAO\/WHO:"},{"key":"bibr5-030089169107700301","volume-title":"(Propiconazole) 1987 evaluations.","author":"FAO\/WHO"},{"key":"bibr6-030089169107700301","volume-title":"FAO\/WHO: Pesticide residues in food (Prochloraz) 1983 and 1985 evaluations."},{"key":"bibr7-030089169107700301","volume-title":"Pesticide residues in food (Benomyl) 1975\/78\/83 evaluations.","author":"FAO\/WHO:"},{"key":"bibr8-030089169107700301","volume-title":"Pesticide residues in food (Chinomethionat) 1968\/74\/77\/81\/84 and 87 evaluations.","author":"FAO\/WHO:"},{"key":"bibr9-030089169107700301","volume-title":"Pesticide residues in food (Daminozide) 1977\/78 and 89 evaluations.","author":"FAO\/WHO:"},{"key":"bibr10-030089169107700301","first-page":"186","volume":"12","author":"Higgins G.M.","year":"1931","journal-title":"Arch. 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