{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:15:44Z","timestamp":1777918544096,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1993,10,1]],"date-time":"1993-10-01T00:00:00Z","timestamp":749433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and Background<\/jats:title>\n                    <jats:p>Symptomatic relief of bone metastases with biphosphonates has been previously reported, but limited data are available on the possibility of the induction of sclerosis in osteolytic lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We therefore initiated an open study with disodium pamidronate (45 mg infused over 1 h and repeated every 21 days) in patients with bone metastases from breast cancer pretreated with chemotherapy and\/or hormonetherapy. Fourteen patients wiht measurable lytic or mixed bone disease entereted the study. No other systemic therapy for breast cancer was allowed after their Inclusion in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No radiologic evidence of bone sclerosis of lytic disease was seen. After 2 months of therapy, 9 patients had progressed and 5 had stable disease. The median time to progression of bone disease was 1.6 months (range, 1-9). No significant improvement in terms of symptomatic status or analgesic consumption was recorded. The treatment was well tolerated, and no significant local or systemic toxicity was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Disodium pamidronate at a dose of 45 mg every 3 weeks is not capable of inducing sclerosis of lytic lesions from pretreated breast cancer. Further trials concentrating on higher dosages of disodium pamidronate are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089169307900511","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T11:15:22Z","timestamp":1524482122000},"page":"340-342","source":"Crossref","is-referenced-by-count":1,"title":["Disodium Pamidronate in the Treatment of Bone Metastases from Breast Cancer"],"prefix":"10.1177","volume":"79","author":[{"given":"Marco","family":"Coileoni","sequence":"first","affiliation":[{"name":"(Division of Medical Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Bochicchio","sequence":"additional","affiliation":[{"name":"(Division of Medical Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Nol\u00e8","sequence":"additional","affiliation":[{"name":"(Division of Medical Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Bajetta","sequence":"additional","affiliation":[{"name":"(Division of Medical Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,10,1]]},"reference":[{"key":"bibr1-030089169307900511","first-page":"27","volume":"1","author":"Boonekamp P.M.","year":"1986","journal-title":"Bone Mineral."},{"key":"bibr2-030089169307900511","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1987.13"},{"key":"bibr3-030089169307900511","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1988.272"},{"key":"bibr4-030089169307900511","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)92755-1"},{"key":"bibr5-030089169307900511","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(86)90117-3"},{"key":"bibr6-030089169307900511","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/8756-3282(87)90128-1","volume":"8","author":"Fleisch H.","year":"1987","journal-title":"Bone"},{"key":"bibr7-030089169307900511","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1992.10.1.134"},{"key":"bibr8-030089169307900511","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890915)64:6<1358::AID-CNCR2820640630>3.0.CO;2-B"},{"key":"bibr9-030089169307900511","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6651.772"},{"key":"bibr10-030089169307900511","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1986.66.4.855"},{"key":"bibr11-030089169307900511","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jbmr.5650040305","volume":"4","author":"Nussbaum S.R.","year":"1989","journal-title":"Bone Miner. Res."},{"key":"bibr12-030089169307900511","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198002073020602"},{"key":"bibr13-030089169307900511","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058287"},{"key":"bibr14-030089169307900511","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(91)90056-J"},{"key":"bibr15-030089169307900511","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.5.762"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169307900511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169307900511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:41:30Z","timestamp":1777660890000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089169307900511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,10]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,10]]}},"alternative-id":["10.1177\/030089169307900511"],"URL":"https:\/\/doi.org\/10.1177\/030089169307900511","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,10]]}}}