{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:15:41Z","timestamp":1777918541926,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1993,10,1]],"date-time":"1993-10-01T00:00:00Z","timestamp":749433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:p>We report our experience with 5 cases of post-Paget osteosarcoma of the skull, a rare lesion of the neurocranium. Four patients were treated by surgery and radiotherapy and one by surgery alone. Two patients received chemotherapy. Histologically, the tumor was found to be an osteosarcoma, fibroblastic in 2 cases, mixed in 2, and osteoblastic in 1. Combined treatment (surgery, radiotherapy and chemotherapy) positively influenced survival (median survival, 6 months). The prognosis for post-Paget osteosarcomas of the skull seems to be worse than for primary sarcomas, probably due to their intense vascularization. This facilitates the spread of tumor cells to other organs (as observed in our cases) and reduces the reduced effectiveness of chemotherapy. Although the latter lengthens survival and reduces the incidence of metastases, it is not as efficacious as in primary sarcomas.<\/jats:p>","DOI":"10.1177\/030089169307900517","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T11:15:22Z","timestamp":1524482122000},"page":"363-366","source":"Crossref","is-referenced-by-count":3,"title":["Post-Paget Osteosarcomas of the Skull. Remarks on Five Cases"],"prefix":"10.1177","volume":"79","author":[{"given":"Maurizio","family":"Salvati","sequence":"first","affiliation":[{"name":"(University of Rome \u00ab La Sapienza \u00bb, Department of Neurological Sciences-Neurosurgery, Rome)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Cervoni","sequence":"additional","affiliation":[{"name":"(University of Rome \u00ab La Sapienza \u00bb, Department of Neurological Sciences-Neurosurgery, Rome)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Raguso","sequence":"additional","affiliation":[{"name":"(University of Rome \u00ab La Sapienza \u00bb, Department of Neurological Sciences-Neurosurgery, Rome)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Raco","sequence":"additional","affiliation":[{"name":"(University of Rome \u00ab La Sapienza \u00bb, Department of Neurological Sciences-Neurosurgery, Rome)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,10,1]]},"reference":[{"key":"bibr1-030089169307900517","first-page":"530","volume-title":"Terapia Medica Oncologica.","author":"Bacci G.","year":"1990"},{"key":"bibr2-030089169307900517","first-page":"173","volume-title":"Bone Tumors. Baillier's Clinical Oncology. International Practice and Researche.","author":"Bramwell V.H.","year":"1987"},{"key":"bibr3-030089169307900517","first-page":"133","volume":"64","author":"Bricout V.H.","year":"1983","journal-title":"J. Radiol."},{"key":"bibr4-030089169307900517","first-page":"79","volume":"1","author":"Cade S.","year":"1955","journal-title":"J. R. Coll. Surg."},{"key":"bibr5-030089169307900517","unstructured":"DahlinD.C., UnniK.K.: Bone tumors, general aspects and data on 8542 cases. 4th ed., pp. 269\u2013321, C.C. Thomas, Springfield, 1986."},{"key":"bibr6-030089169307900517","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.1.21"},{"key":"bibr7-030089169307900517","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198512263132605"},{"key":"bibr8-030089169307900517","first-page":"169","volume":"130","author":"Henin D.","year":"1979","journal-title":"Ann. Med. Interne"},{"key":"bibr9-030089169307900517","first-page":"85","volume-title":"Diagnosis, Treatment and Prognosis","author":"Huvos A.G.","year":"1991"},{"key":"bibr10-030089169307900517","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1489::AID-CNCR2820520826>3.0.CO;2-X"},{"key":"bibr11-030089169307900517","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850901)56:5<1214::AID-CNCR2820560543>3.0.CO;2-8"},{"key":"bibr12-030089169307900517","unstructured":"KiefferS.A., LongD.M., ChouS.N., KingG.A., CacayorinE.D.: In: Neurological Surgery, 3 ed. YoumanJ.R. (Ed.), pp. 3593\u20133683, W.B. Saunders, Philadelphia, 1990."},{"key":"bibr13-030089169307900517","first-page":"379","volume":"9","author":"Lee Y.Y.","year":"1988","journal-title":"AJNR"},{"key":"bibr14-030089169307900517","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606193142502"},{"key":"bibr15-030089169307900517","first-page":"1418","volume-title":"Principles and Practice of Oncology.","author":"Malawer M.M.","year":"1989"},{"key":"bibr16-030089169307900517","first-page":"414","volume":"29","author":"Metha R.C.","year":"1988","journal-title":"J. Nucl. Med."},{"key":"bibr17-030089169307900517","first-page":"21","volume-title":"Bone tumors. Bailliere's Clinical Oncology. Clinical Practice and Research.","author":"Pringle J.A.S.","year":"1983"},{"key":"bibr18-030089169307900517","first-page":"743","volume-title":"The Skull.","volume":"1","author":"Romeo E.","year":"1971"},{"key":"bibr19-030089169307900517","first-page":"533","volume-title":"Cancer Treatment","author":"Rosen G.","year":"1990"},{"key":"bibr20-030089169307900517","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820315)49:6<1221::AID-CNCR2820490625>3.0.CO;2-E"},{"key":"bibr21-030089169307900517","first-page":"544","volume-title":"Cancer Chemotherapy and Biological Response Modifiers.","author":"Santoro A.","year":"1990"},{"key":"bibr22-030089169307900517","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.25.45"},{"key":"bibr23-030089169307900517","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.152.3.6235535"},{"key":"bibr24-030089169307900517","first-page":"1","volume-title":"Bone Tumors. Bailliere's Clinical Oncology. International Practice and Research.","author":"Souhami R.","year":"1987"},{"key":"bibr25-030089169307900517","first-page":"86","volume-title":"Diagnosis and clinical management.","author":"Sundaresan N.","year":"1990"},{"key":"bibr26-030089169307900517","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198101000-00008"},{"key":"bibr27-030089169307900517","first-page":"428","volume":"24","author":"Yochum T.R.","year":"1984","journal-title":"Radiologe"},{"key":"bibr28-030089169307900517","first-page":"814","volume-title":"Cancer Epidemiology and Prevention.","author":"Young J.L.","year":"1982"},{"key":"bibr29-030089169307900517","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198304000-00015"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169307900517","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169307900517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:41:32Z","timestamp":1777660892000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089169307900517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,10]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,10]]}},"alternative-id":["10.1177\/030089169307900517"],"URL":"https:\/\/doi.org\/10.1177\/030089169307900517","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,10]]}}}