{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:15:45Z","timestamp":1777918545072,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1993,12,1]],"date-time":"1993-12-01T00:00:00Z","timestamp":754704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1993,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>A comparative analysis was performed to verify a possible correlation between mammographic features and morphobiologic characteristics of the tumor in a series of 176 invasive primary breast cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Breast cancers were grouped according to mammographic features as follows: tumor mass with spiculated borders; tumor mass with well-circumscribed borders; tumor with density alteration of parenchyma with no clear borders; a cluster of micro-calcifications as the only sign of tumor presence; tumor without mammographic abnormality. The tumor tissue biologic characteristics investigated were: hormone receptor content, tumor proliferative activity, DNA content and cytohlstologic tumor-grade differentiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Spiculated tumors showed a significantly higher percentage of estrogen-receptorpositive cases with respect to circumscribed tumors, independently of the patient's menopausal status. Tumors with only microcalcifications were all from premenopausal patients and showed a significantly higher percentage of progesterone-receptor-positive cases (83 %). Tumor proliferative activity did not significantly differ in the 5 mammographic breast cancer groups; aneuploidy was less frequent in tumors with spiculated borders than in mammographic types (39 % vs 57 %; p = 0.05); percentages of G1-G2-G3 tumors did not differ significantly among the mammographic groups considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Certain relationships between mammographic features and biologic characteristics could be of potential clinical interest and stimulate more detailed studies on this issue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089169307900611","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T11:13:47Z","timestamp":1524482027000},"page":"422-426","source":"Crossref","is-referenced-by-count":4,"title":["Mammography and Morphobiologic Characteristics of Human Breast Cancer"],"prefix":"10.1177","volume":"79","author":[{"given":"Angelo","family":"Paradiso","sequence":"first","affiliation":[{"name":"Experimental and Clinical Oncology Laboratory, Oncology Institute, Bari"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annita","family":"Mangia","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Oncology Laboratory, Oncology Institute, Bari"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Barletta","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Oncology Laboratory, Oncology Institute, Bari"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Marzullo","sequence":"additional","affiliation":[{"name":"Histopathology Service, Oncology Institute, Bari"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Ventrella","sequence":"additional","affiliation":[{"name":"Radio Diagnostic Division, Oncology Institute, Bari"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Racanelli","sequence":"additional","affiliation":[{"name":"Radio Diagnostic Division, Oncology Institute, Bari"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Schittulli","sequence":"additional","affiliation":[{"name":"Senology and Surgical Prevention, Oncology Institute, Bari"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"De Lena","sequence":"additional","affiliation":[{"name":"Medical Oncology Division, Oncology Institute, Bari"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,12,1]]},"reference":[{"key":"bibr1-030089169307900611","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1968.6"},{"key":"bibr2-030089169307900611","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921001)70:7<1928::AID-CNCR2820700720>3.0.CO;2-R"},{"key":"bibr3-030089169307900611","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921001)70:7<1935::AID-CNCR2820700721>3.0.CO;2-W"},{"key":"bibr4-030089169307900611","first-page":"50","volume":"375","author":"Bjurstam N.G.","year":"1978","journal-title":"Acta Radiol. 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