{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:16:21Z","timestamp":1777918581404,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and background<\/jats:title>\n                    <jats:p>The goal of the study was to report and discuss the neoplastic and non-neoplastic diseases of the thyroid gland present in a historical series of surgical material examined during the period 1945 to 1989 at the Pathology Department of the Sao Paulo University Medical School.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Records of 281,175 cases were reviewed to select those which affected the thyroid gland. The slides of these selected cases were analyzed and classified according to current terminology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Non-neoplastic lesions comprised 86.68% of the cases (n = 7024), and most of them were nodular goiter (n = 6458). Neoplastic lesions were divided into two groups: primary and metastatic. Of 1072 primary neoplasms, 530 were benign and 542 were malignant. Of the malignant neoplasms, papillary and follicular were the most frequent types (n = 201 and 187, respectively), followed by undifferentiated (n = 86), H\u00fcrthle (n = 46), medullary (n = 16) and others (n = 6). Of 8 metastatic neoplasms, 4 were from and undetermined primary epidermoid carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We concluded that owing to the high incidence of neoplastic lesions (13.32%), half of which were malignant, examination of the thyroid gland should be done with strict criteria in view of the therapeutic and prognostic implications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089169508100115","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:28:37Z","timestamp":1523942917000},"page":"63-66","source":"Crossref","is-referenced-by-count":6,"title":["Neoplastic and Non-Neoplastic Thyroid Lesions in Surgical Material: Historical Review of Five Decades in S\u00e3o Paulo, Brazil"],"prefix":"10.1177","volume":"81","author":[{"given":"Helio","family":"Bisi","sequence":"first","affiliation":[{"name":"Pathology Department, Faculdade de Medicina, Universidade de S\u00e3o Paulo, and Pathology Division, Istituto Adolfo Lutz, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilma S.O.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculdade de Medicina, Universidade de S\u00e3o Paulo, and Pathology Division, Istituto Adolfo Lutz, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Rosalinda","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculdade de Medicina, Universidade de S\u00e3o Paulo, and Pathology Division, Istituto Adolfo Lutz, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asato","family":"De Camargo","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculdade de Medicina, Universidade de S\u00e3o Paulo, and Pathology Division, Istituto Adolfo Lutz, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adhemar Longatto","family":"Filho","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculdade de Medicina, Universidade de S\u00e3o Paulo, and Pathology Division, Istituto Adolfo Lutz, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glaucia Berreta","family":"Ruggeri","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculdade de Medicina, Universidade de S\u00e3o Paulo, and Pathology Division, Istituto Adolfo Lutz, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anete H.","family":"Abdo","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculdade de Medicina, Universidade de S\u00e3o Paulo, and Pathology Division, Istituto Adolfo Lutz, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,1,1]]},"reference":[{"key":"bibr1-030089169508100115","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197806)41:6<2267::AID-CNCR2820410627>3.0.CO;2-7"},{"key":"bibr2-030089169508100115","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.39.5.483"},{"key":"bibr3-030089169508100115","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19891101)64:9<1888::AID-CNCR2820640922>3.0.CO;2-C"},{"key":"bibr4-030089169508100115","first-page":"232","volume":"51","author":"Farooki M.A.","year":"1969","journal-title":"Int. Surg."},{"key":"bibr5-030089169508100115","first-page":"317","volume":"51","author":"Farooki M.A.","year":"1969","journal-title":"Int. Surg."},{"key":"bibr6-030089169508100115","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(82)80306-7"},{"key":"bibr7-030089169508100115","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1978.tb01710.x"},{"key":"bibr8-030089169508100115","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197303000-00003"},{"key":"bibr9-030089169508100115","first-page":"291","volume":"59","author":"Hull O.H.","year":"1955","journal-title":"Arch. Pathol."},{"key":"bibr10-030089169508100115","first-page":"136","volume-title":"Surgical Pathology of Thyroid. Vol. 22, Major problems in pathology","author":"Li Volsi V.A.","year":"1990"},{"key":"bibr11-030089169508100115","first-page":"173","volume-title":"In: Surgical Pathology of Thyroid. Vol. 22, Major problems in pathology","author":"Li Volsi V.A.","year":"1990"},{"key":"bibr12-030089169508100115","first-page":"253","volume-title":"In: Surgical Pathology of Thyroid","volume":"22","author":"Li Volsi V.A.","year":"1990"},{"key":"bibr13-030089169508100115","first-page":"323","volume-title":"In: Surgical Pathology of Thyroid","volume":"22","author":"Li Volsi V.S.","year":"1990"},{"key":"bibr14-030089169508100115","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-15-10-1270"},{"key":"bibr15-030089169508100115","first-page":"432","volume":"67","author":"Naylor B.","year":"1959","journal-title":"Arch. Pathol."},{"key":"bibr16-030089169508100115","first-page":"297","volume-title":"In: Tumors of the Thyroid Gland. Fasc. 5. 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