{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:29:03Z","timestamp":1790908143359,"version":"4.1.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1995,7,1]],"date-time":"1995-07-01T00:00:00Z","timestamp":804556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and background<\/jats:title>\n                    <jats:p>Recombinant alpha-interferon has been shown to be effective in essential thrombocythemia and in thrombocytosis associated with other myeloproliferative disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>\n                      Twenty-five untreated patients were enrolled in our study from May 1989 to April 1992. Recombinant alpha interferon-2b was administered at an initial dose of 2 megaunits (MU)\/m\n                      <jats:sup>2<\/jats:sup>\n                      three times a week at escalating doses to 5 MU\/m\n                      <jats:sup>2<\/jats:sup>\n                      or the maximum tolerated dose. The mean follow-up for patients still in treatment at the time of this report was 35.9 months (range, 24-63).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fourteen patients (56%) had achieved a complete remission by a mean time of 152 days; 6 patients (24%) had achieved a good partial remission by a mean of 180 days. In addition to the favorable effect on platelet count, a marked improvement in clinical symptoms was observed. Treatment had to be discontinued in 9 patients (36%), 5 for toxicity (3 neurologic, 1 anemia and 1 severe hypertriglyceridemia) at a median of 155 days from the beginning of therapy (range, 30-400). Four patients refused to continue therapy because of low tolerance (flu-like syndrome) at mean of 160 days from the beginning of therapy (range, 34-301).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In our study, lower doses were administered compared with previous short-time trials. The present data show that interferon is an effective alternative to cytostatic agents in long-term treatment of patients with essential thrombocythemia, even when used at lower dosages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089169508100406","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T11:15:25Z","timestamp":1524482125000},"page":"245-248","source":"Crossref","is-referenced-by-count":13,"title":["Alpha Interferon as Initial Treatment of Essential Thrombocythemia. Analysis after Two Years of Follow-Up"],"prefix":"10.1177","volume":"81","author":[{"given":"Enrico Maria","family":"Pogliani","sequence":"first","affiliation":[{"name":"Hematology Unit, Monza Hospital, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Rossini","sequence":"additional","affiliation":[{"name":"Hematology Unit, Monza Hospital, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Miccolis","sequence":"additional","affiliation":[{"name":"Hematology Unit, Monza Hospital, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Ferrarlo","sequence":"additional","affiliation":[{"name":"Medical Division, Vimercate Hospital, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Perego","sequence":"additional","affiliation":[{"name":"Medical Division, Desio Hospital, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Casaroli","sequence":"additional","affiliation":[{"name":"Hematology Unit, Monza Hospital, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bolis","sequence":"additional","affiliation":[{"name":"Hematology Unit, Monza Hospital, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Fagnani","sequence":"additional","affiliation":[{"name":"Medical Division, Vimercate Hospital, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Medical Division, Desio Hospital, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmarco","family":"Corneo","sequence":"additional","affiliation":[{"name":"Hematology Unit, Monza Hospital, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1995,7,1]]},"reference":[{"key":"bibr1-030089169508100406","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861201)58:11<2440::AID-CNCR2820581115>3.0.CO;2-Y"},{"key":"bibr2-030089169508100406","doi-asserted-by":"publisher","DOI":"10.1038\/313531a0"},{"key":"bibr3-030089169508100406","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1650172"},{"key":"bibr4-030089169508100406","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V70.4.1173.1173"},{"key":"bibr5-030089169508100406","doi-asserted-by":"publisher","DOI":"10.3109\/10428199009050983"},{"key":"bibr6-030089169508100406","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(91)90579-3"},{"key":"bibr7-030089169508100406","first-page":"447","volume-title":"The Biology of Alpha-Interferon System","author":"Gisslinger H."},{"key":"bibr8-030089169508100406","first-page":"442","volume":"4","author":"Lazzarino M.","year":"1992","journal-title":"Forum"},{"key":"bibr9-030089169508100406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb07679.x"},{"key":"bibr10-030089169508100406","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830330106"},{"key":"bibr11-030089169508100406","first-page":"177","volume":"23","author":"Murphy S.","year":"1986","journal-title":"Semin. Haematol."},{"key":"bibr12-030089169508100406","first-page":"73","volume":"87","author":"Pogliani E.M.","year":"1993","journal-title":"Ospedale Maggiore"},{"key":"bibr13-030089169508100406","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V64.1.1.1"},{"key":"bibr14-030089169508100406","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.5.1280.1280"},{"key":"bibr15-030089169508100406","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(89)90384-7"},{"key":"bibr16-030089169508100406","first-page":"719","volume-title":"Balliere's Clinical Haematology.","volume":"2","author":"Tobelem G."},{"key":"bibr17-030089169508100406","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(91)90578-2"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169508100406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169508100406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:42:50Z","timestamp":1777660970000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089169508100406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1177\/030089169508100406"],"URL":"https:\/\/doi.org\/10.1177\/030089169508100406","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}