{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:16:31Z","timestamp":1777918591395,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1995,7,1]],"date-time":"1995-07-01T00:00:00Z","timestamp":804556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:p>Mink cell focus-forming viruses (MCF) are slow-transforming retroviruses that are able to accelerate the appearance of T-cell lymphomas when injected in newborn AKR mice. Activation of proto-oncogenes by proviral insertion is thought to be the major mechanism by which these viruses exert their oncogenic potential. However, molecular phenomena not strictly virus-determined, such as mutations in cellular oncogenes\/tumor suppressor genes or chromosome aberrations, have been hypothesized to contribute to the achievement of the fully neoplastic phenotype in MCF-infected mice. To evaluate the role of spontaneous mutagenesis phenomena in murine virus-induced lymphomagenesis, we analyzed a series of 18 MCF247-induced thymic lymphomas and derived cell lines for the presence of p53 and c-ras gene mutations. Only 1 mutation at the p53 gene and 1 mutation at the ki-ras gene were detected in our study. Our results suggest that spontaneous mutagenesis plays a minor role in virus-induced lymphomagenesis and support the notion that multiple proviral insertions could be the prevalent mechanism of transformation in this experimental system.<\/jats:p>","DOI":"10.1177\/030089169508100411","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T11:15:25Z","timestamp":1524482125000},"page":"268-272","source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous Mutation of Cell Oncogenes Plays a Minor Role in Neoplastic Transformation of Virus-Induced Murine T-Cell Lymphomas"],"prefix":"10.1177","volume":"81","author":[{"given":"Daniela","family":"Gasparotto","sequence":"first","affiliation":[{"name":"Department of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano (PN), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Maestro","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano (PN), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Vukosavljevic","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano (PN), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Piccinin","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano (PN), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Sandrin","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano (PN), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano (PN), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Boiocchi","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano (PN), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,7,1]]},"reference":[{"key":"bibr1-030089169508100411","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.19.7495"},{"key":"bibr2-030089169508100411","doi-asserted-by":"publisher","DOI":"10.1177\/030089168407000601"},{"key":"bibr3-030089169508100411","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(90)90007-V"},{"key":"bibr4-030089169508100411","first-page":"4682","volume":"49","author":"Bos J.L.","year":"1989","journal-title":"Cancer Res."},{"key":"bibr5-030089169508100411","first-page":"3791","volume":"52","author":"Brathwaite O.","year":"1992","journal-title":"Cancer Res."},{"key":"bibr6-030089169508100411","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.12.3205.3205"},{"key":"bibr7-030089169508100411","doi-asserted-by":"publisher","DOI":"10.1038\/362849a0"},{"key":"bibr8-030089169508100411","doi-asserted-by":"publisher","DOI":"10.1084\/jem.151.3.542"},{"key":"bibr9-030089169508100411","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.6.2657"},{"key":"bibr10-030089169508100411","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.60.1.230-241.1986"},{"key":"bibr11-030089169508100411","doi-asserted-by":"publisher","DOI":"10.1038\/356215a0"},{"key":"bibr12-030089169508100411","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb07837.x"},{"key":"bibr13-030089169508100411","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5413"},{"key":"bibr14-030089169508100411","first-page":"4855","volume":"54","author":"Greenblatt M.S.","year":"1994","journal-title":"Cancer Res."},{"key":"bibr15-030089169508100411","volume-title":"Oncogenic Viruses","author":"Gross L.","year":"1970"},{"key":"bibr16-030089169508100411","first-page":"219","volume":"19","author":"Hays E.F.","year":"1992","journal-title":"Thymus"},{"key":"bibr17-030089169508100411","doi-asserted-by":"publisher","DOI":"10.1038\/362847a0"},{"key":"bibr18-030089169508100411","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V71.6.1707.1707"},{"key":"bibr19-030089169508100411","first-page":"1159","volume":"7","author":"Maestro R.","year":"1992","journal-title":"Oncogene"},{"key":"bibr20-030089169508100411","first-page":"229","volume":"3","author":"Mangues R.","year":"1992","journal-title":"Semin. 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