{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:16:42Z","timestamp":1777918602182,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and Background<\/jats:title>\n                    <jats:p>To improve local control in patients with locally advanced inoperable head and neck cancer we administered carboplatin concurrently with radiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty-nine patients entered the study. There were 35 men and 4 women with a median age of 58 years (range, 24-74) and a median performance status of 90 (range, 60-100) of the Karnofsky scale. The primary site included nasopharynx (5 patients), oropharynx (n=10), hypopharynx (n=5), larynx (n=12), oral cavity (n=2), paranasal sinuses (n=3), salivary glands (n=1) and unknown (n=1). Histology was squamous cell carcinoma in all cases. All patients were irradiated with a\n                      <jats:sup>60<\/jats:sup>\n                      Co unit. According to the protocol, they should receive 66-70 Gy to the tumor area and 45 Gy to the tumor-free area of the neck. Carboplatin was administered at a dose of 400 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      on days 2, 22 and 42.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Totally, 112 cycles of carboplatin were administered, of which 106 (95%) were at full dose. Median dose intensity of carboplatin actually delivered was 170 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/week (range, 57-200). All patients were irradiated, although only 30 (77%) received &gt;66 Gy. After the completion of combined treatment, 23 (59%, 95% C.I. 42-74%) achieved a CR and 10 (26%, 95% C.I. 13-42%) a PR. Grade 3-4 myelotoxicity was noticed in 60% of the patients. Other grade 3-4 toxicities included stomatitis (13%), dysphagia (5%) and weight loss (3%). Median time to progression was 18 months (range, 2-25).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Radiation and concurrent administration of carboplatin determined a high CR rate in patients with HNC, although the superiority of this combined modality approach over radiation alone has to be proven in phase III trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089169508100510","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T11:12:42Z","timestamp":1524481962000},"page":"354-358","source":"Crossref","is-referenced-by-count":5,"title":["Radiation and Concurrent Carboplatin Administration in Locally Advanced Head and Neck Cancer"],"prefix":"10.1177","volume":"81","author":[{"name":"A Hellenic Cooperative Oncology Group Study","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Fountzilas","sequence":"additional","affiliation":[{"name":"AHEPA Hospital, Aristotle University, Thessaloniki, Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimosthenis","family":"Skarlos","sequence":"additional","affiliation":[{"name":"\u201cAgii Anargiri\u201d Cancer Hospital, Athens"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelos","family":"Nikolaou","sequence":"additional","affiliation":[{"name":"AHEPA Hospital, Aristotle University, Thessaloniki, Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kalogera-Fountzila","sequence":"additional","affiliation":[{"name":"AHEPA Hospital, Aristotle University, Thessaloniki, Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Tzitzikas","sequence":"additional","affiliation":[{"name":"AHEPA Hospital, Aristotle University, Thessaloniki, Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paris","family":"Kosmidis","sequence":"additional","affiliation":[{"name":"\u201cMETAXA\u201d Cancer Hospital, Piraeous"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paris","family":"Makrantonakis","sequence":"additional","affiliation":[{"name":"AHEPA Hospital, Aristotle University, Thessaloniki, Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Epaminontas","family":"Samantas","sequence":"additional","affiliation":[{"name":"\u201cAgii Anargiri\u201d Cancer Hospital, Athens"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Karpasitis","sequence":"additional","affiliation":[{"name":"\u201cAgii Anargiri\u201d Cancer Hospital, Athens"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haralambos","family":"Bacoyiannis","sequence":"additional","affiliation":[{"name":"\u201cMETAXA\u201d Cancer Hospital, Piraeous"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Synodinou","sequence":"additional","affiliation":[{"name":"\u201cMETAXA\u201d Cancer Hospital, Piraeous"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Pavlidis","sequence":"additional","affiliation":[{"name":"University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristoteles","family":"Vritsios","sequence":"additional","affiliation":[{"name":"AHEPA Hospital, Aristotle University, Thessaloniki, Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Daniilidis","sequence":"additional","affiliation":[{"name":"AHEPA Hospital, Aristotle University, Thessaloniki, Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,9,1]]},"reference":[{"key":"bibr1-030089169508100510","unstructured":"American Joint Committee on Cancer. Manual for Staging on Cancer (3rd ed). p. 27\u201351, J.B. Lippincott, Philadelphia, 1988."},{"key":"bibr2-030089169508100510","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.11.1748"},{"key":"bibr3-030089169508100510","doi-asserted-by":"publisher","DOI":"10.1016\/0305-7372(85)90026-X"},{"key":"bibr4-030089169508100510","doi-asserted-by":"publisher","DOI":"10.1016\/0305-7372(88)90029-1"},{"key":"bibr5-030089169508100510","first-page":"275","volume":"6","author":"Eschwege F.","year":"1988","journal-title":"J. Natl. Cancer Inst. 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Fourth International Congress of Anti-Cancer Chemotherapy, Paris, France, p. 73, 1993."},{"key":"bibr12-030089169508100510","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(80)80069-9"},{"key":"bibr13-030089169508100510","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870801)60:3<301::AID-CNCR2820600306>3.0.CO;2-V"},{"key":"bibr14-030089169508100510","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890060305"},{"key":"bibr15-030089169508100510","first-page":"471","volume":"7","author":"Vokes E.E.","year":"1989","journal-title":"Clin. 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