{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T09:58:46Z","timestamp":1784973526290,"version":"3.55.0"},"reference-count":9,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1995,11,1]],"date-time":"1995-11-01T00:00:00Z","timestamp":815184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and background<\/jats:title>\n                    <jats:p>In addition to well-documented endocrine properties of interleukins, hemopoietic growth factors could also exert hormonal activities. In fact, our previous studies have shown that GM-CSF may stimulate cortisol and GH release. In contrast, few data only are available about the possible effects of G-CSF. This study was carried out to investigate endocrine effects of G-CSF in cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 8 cancer patients who were investigated after G-CSF (0.3 mg subcutaneously) or during saline infusion alone as control by collecting venous samples at zero time and after 2, 4, 6 and 8 h. Serum levels of cortisol, GH, PRL, FSH. LH, TSH and melatonin were measured by the RIA method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The circadian rhythm of cortisol was not influenced by G-CSF. No significant differences in mean levels of GH, PRL, FSH or LH were seen after G-CSF and during saline infusion. Both TSH and melatonin decreased after G-CSF, without, however, significant differences with respect to the values seen on saline alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study showed that G-CSF has no substantial endocrine affects in humans. Therefore, G-CSF would differ from GM-CSF not only for its hemopoietic properties, but also from an endocrine point of view.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089169508100611","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T11:12:29Z","timestamp":1524481949000},"page":"438-439","source":"Crossref","is-referenced-by-count":7,"title":["Endocrine Effects of Granulocyte Colony-Stimulating Factor in Cancer Patients"],"prefix":"10.1177","volume":"81","author":[{"given":"Franco","family":"Rovelli","sequence":"first","affiliation":[{"name":"Laboratorio Analisi, Ospedale San Gerardo, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Barni","sequence":"additional","affiliation":[{"name":"Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Tancini","sequence":"additional","affiliation":[{"name":"Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ardizzoia","sequence":"additional","affiliation":[{"name":"Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Lissoni","sequence":"additional","affiliation":[{"name":"Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1995,11,1]]},"reference":[{"key":"bibr1-030089169508100611","doi-asserted-by":"publisher","DOI":"10.1007\/BF01729833"},{"key":"bibr2-030089169508100611","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198702123160705"},{"key":"bibr3-030089169508100611","first-page":"142","volume":"6","author":"Crispino S.","year":"1992","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"bibr4-030089169508100611","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-69-2-402"},{"key":"bibr5-030089169508100611","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1989.2"},{"key":"bibr6-030089169508100611","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91103-2"},{"key":"bibr7-030089169508100611","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1988.03410220081032"},{"key":"bibr8-030089169508100611","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90181-C"},{"key":"bibr9-030089169508100611","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93206-3"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169508100611","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169508100611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:43:09Z","timestamp":1777660989000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089169508100611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,11]]}},"alternative-id":["10.1177\/030089169508100611"],"URL":"https:\/\/doi.org\/10.1177\/030089169508100611","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,11]]}}}