{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:18:16Z","timestamp":1777918696518,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1996,11,1]],"date-time":"1996-11-01T00:00:00Z","timestamp":846806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1996,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and Background<\/jats:title>\n                    <jats:p>Various attempts have been made to prevent 5-fluorouracil-induced stomatitis, with unsatisfactory results. Sucralfate is an aluminum hydroxide, complex of sulfated sucrose commonly used in the treatment of gastroduodenal ulcers. We used the compound in a phase II study to reduce and minimize the stomatotoxicity of 5-fluorouracil chemotherapy administered in a multiple-day schedule.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-two patients entered the study, and 129 cycles of chemotherapy were evaluated. Seven patients refused sucralfate rinses for taste intolerance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A low level of stomatotoxicity was recorded: grade 2 stomatitis was observed after 14 cycles (10.8%) and grade 3 after 3 cycles (2.3%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sucralfate administration could have a role in the prevention of 5-fluorouracil-induced stomatitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089169608200614","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T11:35:53Z","timestamp":1524483353000},"page":"585-587","source":"Crossref","is-referenced-by-count":4,"title":["Sucralfate Prophylaxis of Fluorouracil-Induced Stomatitis"],"prefix":"10.1177","volume":"82","author":[{"given":"Francesca","family":"Giorgi","sequence":"first","affiliation":[{"name":"Oncology Unit, Ospedale Madonna del Soccorso, San Benedetto del Tronto"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romeo","family":"Bascioni","sequence":"additional","affiliation":[{"name":"Oncology Unit, Ospedale Murri, Fermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"De Signoribus","sequence":"additional","affiliation":[{"name":"Oncology Unit, Ospedale Madonna del Soccorso, San Benedetto del Tronto"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Di Saverio","sequence":"additional","affiliation":[{"name":"Oncology Unit, Ospedale Madonna del Soccorso, San Benedetto del Tronto"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,11,1]]},"reference":[{"key":"bibr1-030089169608200614","volume-title":"Handbook for reporting results of cancer treatment.","author":"Anonymous","year":"1979"},{"key":"bibr2-030089169608200614","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-199304000-00006"},{"key":"bibr3-030089169608200614","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1992.10.6.969"},{"key":"bibr4-030089169608200614","first-page":"93","volume":"9","author":"Loprinzi C.L.","year":"1990","journal-title":"NCI Monogr."},{"key":"bibr5-030089169608200614","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900415)65:8<1879::AID-CNCR2820650834>3.0.CO;2-8"},{"key":"bibr6-030089169608200614","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1986.4.5.685"},{"key":"bibr7-030089169608200614","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.3.449"},{"key":"bibr8-030089169608200614","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110033251407"},{"key":"bibr9-030089169608200614","doi-asserted-by":"publisher","DOI":"10.3109\/02841869009090032"},{"key":"bibr10-030089169608200614","doi-asserted-by":"publisher","DOI":"10.3109\/02841869009126540"},{"key":"bibr11-030089169608200614","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608143150717"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169608200614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169608200614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:44:11Z","timestamp":1777661051000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089169608200614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,11]]}},"alternative-id":["10.1177\/030089169608200614"],"URL":"https:\/\/doi.org\/10.1177\/030089169608200614","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,11]]}}}