{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:19:03Z","timestamp":1777918743223,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1997,5,1]],"date-time":"1997-05-01T00:00:00Z","timestamp":862444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1997,5]]},"abstract":"<jats:p>An interesting multiple tumor case is described in which 4 different kinds of tumors were diagnosed in the same patient at autopsy and histopathologic examination. The tumors were the following: 1) prolactinoma of the anterior pituitary lobe; 2) basal cell carcinoma of the nose; 3) adenocarcinoma of the colon sigmoideum; 4) multiple oncocytomas (oncocytomatosis) in the kidneys. Immunohistochemical investigation for p53 revealed a strong intranuclear positivity in the colonic carcinoma cells as a result of the overexpression of a possible mutant type of the protein. The other 3 tumors were negative with the p53-specific DO-7 antibody, therefore, no point mutation was thought to be present in the p53 gene of the tumor cells. The immunohistochemical and anamnestic data suggested that this is not a hereditary syndrome, and there is no common pathogenesis of these tumors. Its rarity is interesting in our case because of the coincidence of 4 different unrelated tumors and the absence of anamnestic data for familial accumulation or predisposition for multiple tumors.<\/jats:p>","DOI":"10.1177\/030089169708300318","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:33:42Z","timestamp":1523943222000},"page":"715-717","source":"Crossref","is-referenced-by-count":1,"title":["Multiple Tumor Case: Report and Analysis of an Autopsy Case"],"prefix":"10.1177","volume":"83","author":[{"given":"Tam\u00e1s","family":"Torn\u00f3czky","sequence":"first","affiliation":[{"name":"Department of Pathology, University Medical School of P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1roly","family":"Szuhai","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Medical School of P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,5,1]]},"reference":[{"key":"bibr1-030089169708300318","doi-asserted-by":"publisher","DOI":"10.1159\/000116986"},{"key":"bibr2-030089169708300318","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072914"},{"key":"bibr3-030089169708300318","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(83)90408-9"},{"key":"bibr4-030089169708300318","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196005052621803"},{"key":"bibr5-030089169708300318","first-page":"2407","volume":"13","author":"Kimura T.","year":"1993","journal-title":"Anticancer Res."},{"key":"bibr6-030089169708300318","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930550207"},{"key":"bibr7-030089169708300318","first-page":"204","volume":"12","author":"Tiszlavicz L.","year":"1993","journal-title":"Clin. Neuropathol."},{"key":"bibr8-030089169708300318","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)54285-8"},{"key":"bibr9-030089169708300318","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)48798-2"},{"key":"bibr10-030089169708300318","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)81116-7"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169708300318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169708300318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:45:09Z","timestamp":1777661109000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089169708300318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,5]]}},"alternative-id":["10.1177\/030089169708300318"],"URL":"https:\/\/doi.org\/10.1177\/030089169708300318","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,5]]}}}