{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:19:03Z","timestamp":1777918743172,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1997,7,1]],"date-time":"1997-07-01T00:00:00Z","timestamp":867715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1997,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and Background<\/jats:title>\n                    <jats:p>To test the feasibility of accelerated interrupted twice-daily radiation and concurrent cisplatin administration in patients with locally advanced head and neck cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Nineteen patients with locally advanced head and neck cancer were treated with accelerated bifractionated radiation with concurrent administration of cisplatin. There were 18 men and 1 female with a median age of 60 years (range, 17\u201371) and median performance status of 90 (-range, 80\u2013100). Sixteen patients (85%) presented with stage IV disease. Primary site included the nasopharynx (n = 7), oropharynx (n = 5), hypopharynx (n = 1) and larynx (n = 6). Radiation consisted of two fractions of 1.6 Gy each daily, five times weekly to a total dose of 64 Gy. Cisplatin was administered at a dose of 100 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      on days 2 and 28 of the treatment period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine patients achieved a complete response (47%; 95% CI, 25%\u201370%) and 5 a partial response (26%; 95% CI, 7%\u201346%). Grade III\u2013IV toxicity included leukopenia (16%), mucositis (26%), dry mouth (5%), weight loss (16%) and infection (5%). After a median follow-up of 27.11 months (range, 1\u201333+), 9 patients have died. Median time to progression was 11 months (range, 1\u201332+) and median survival 25 months (range, 1\u201332+).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Accelerated twice-daily radiation with concurrent cisplatin is effective in locally advanced head and neck cancer and can be safely given with manageable toxicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089169708300404","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:36:34Z","timestamp":1523882194000},"page":"735-739","source":"Crossref","is-referenced-by-count":2,"title":["Accelerated Bifractionated Radiation with Concurrent Cisplatin Administration in Locally Advanced Head and Neck Cancer: A Feasibility Study"],"prefix":"10.1177","volume":"83","author":[{"given":"George","family":"Fountzilas","sequence":"first","affiliation":[{"name":"AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanassios","family":"Athanassiadis","sequence":"additional","affiliation":[{"name":"AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelos","family":"Nikolaou","sequence":"additional","affiliation":[{"name":"AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kalogera-Fountzila","sequence":"additional","affiliation":[{"name":"AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Tzitzikas","sequence":"additional","affiliation":[{"name":"AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Epaminontas","family":"Samantas","sequence":"additional","affiliation":[{"name":"\u201cAgii Anargyri\u201d Cancer Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimosthenis","family":"Skarlos","sequence":"additional","affiliation":[{"name":"\u201cAgii Anargyri\u201d Cancer Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaos","family":"Zamboglou","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine, Stadtische Kliniken Offenbach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Daniilidis","sequence":"additional","affiliation":[{"name":"AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,7,1]]},"reference":[{"key":"bibr1-030089169708300404","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870115)59:2<259::AID-CNCR2820590214>3.0.CO;2-1"},{"key":"bibr2-030089169708300404","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90226-A"},{"key":"bibr3-030089169708300404","first-page":"293","volume":"14","author":"Bensadoun R.J.","year":"1995","journal-title":"Proc. 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