{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:19:15Z","timestamp":1777918755155,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:p>We report two cases of Merkel cell carcinoma within inguinal and axillary lymph nodes, respectively, showing no clinicopathologic evidence of a primary (extranodal) tumor; one of our patients was alive with no evidence of disease five years and ten months after the surgical excision of the neoplasm with no postoperative chemotherapy.<\/jats:p>\n                  <jats:p>The diagnosis of nodal Merkel cell carcinoma needs to be supported by a careful immunohistochemical study: in fact, cytokeratin- and neurofilament-positive paranuclear \u201cdots\u201d, as well as epithelial antigens and neuroendocrine markers may be variably expressed in tumor cells, thus requiring the application of a complete antibody panel.<\/jats:p>\n                  <jats:p>In the presence of a nodal Merkel cell tumor, an exhaustive clinico-radiologic search for a primary tumor must be carried out. After the exclusion of any reasonable starting point of the neoplasm, a provisional diagnosis of \u201cprimary\u201d nodal Merkel cell carcinoma may be acceptable; since a primary extracutaneous tumor is expected to follow a less aggressive course than a metastatic one, follow-up data may provide indications as to the truly extracutaneous origin of Merkel cell carcinoma.<\/jats:p>","DOI":"10.1177\/030089169708300518","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:24:05Z","timestamp":1523881445000},"page":"868-872","source":"Crossref","is-referenced-by-count":15,"title":["Lymph Node Merkel Cell Carcinoma with No Evidence of Cutaneous Tumor - Report of Two Cases"],"prefix":"10.1177","volume":"83","author":[{"given":"Gerardo","family":"Ferrara","sequence":"first","affiliation":[{"name":"Servizio di Anatomia Patologica, Azienda Ospedaliera \u201cG. 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