{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:19:15Z","timestamp":1777918755157,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and background<\/jats:title>\n                    <jats:p>The metastatic spread of squamous cell carcinoma of the head and neck (SCCHN) to the cervical lymph nodes is a negative prognostic factor in terms of survival. We have used multivariate analysis to identify the possible prognostic significance of a number of clinical and pathological characteristics in relation to possible involvement of the cervical lymph nodes in a series of 396 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>396 patients with SCCHN were studied. Variables regarding the patient, the carcinoma and histology were analysed by multivariate analysis using BMDP's PLR programme.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Some variables appear to represent predisposing factors for tumor spread to the lymph nodes: tumor site (supraglottic larynx: P=0.005; base of the tongue: P=0.02; hypopharynx: P=0.02), grading (P=0.001), and a number of histological parameters (lower degree of histological differentiation: P=0.001; vascular permeation: P=0.04; perineural invasion: P&lt;0.05; prevalently plasmocytic infiltrate: P&lt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The identification of cases at risk for metastasis can be improved by the assessment of prognostic factors, with a consequent improvement in treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089169708300610","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T11:21:55Z","timestamp":1524482515000},"page":"922-926","source":"Crossref","is-referenced-by-count":28,"title":["Prognostic Factors of Cervical Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma"],"prefix":"10.1177","volume":"83","author":[{"given":"Mauro","family":"Magnano","sequence":"first","affiliation":[{"name":"Second Ear, Nose and Throat Clinic, University of Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"De Stefani","sequence":"additional","affiliation":[{"name":"Second Ear, Nose and Throat Clinic, University of Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Lerda","sequence":"additional","affiliation":[{"name":"Second Ear, Nose and Throat Clinic, University of Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Usai","sequence":"additional","affiliation":[{"name":"Second Ear, Nose and Throat Clinic, University of Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Ragona","sequence":"additional","affiliation":[{"name":"Institute of Radiology, University of Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Bussi","sequence":"additional","affiliation":[{"name":"Second Ear, Nose and Throat Clinic, University of Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Cortesina","sequence":"additional","affiliation":[{"name":"Second Ear, Nose and Throat Clinic, University of Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,11,1]]},"reference":[{"key":"bibr1-030089169708300610","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5541030405"},{"key":"bibr2-030089169708300610","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(85)80033-5"},{"key":"bibr3-030089169708300610","doi-asserted-by":"publisher","DOI":"10.1007\/BF00181086"},{"key":"bibr4-030089169708300610","volume-title":"BMDP Statistical Software.","year":"1985"},{"key":"bibr5-030089169708300610","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1989.01860350038011"},{"key":"bibr6-030089169708300610","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199507000-00001"},{"key":"bibr7-030089169708300610","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1987.01860120053007"},{"key":"bibr8-030089169708300610","first-page":"854","volume":"103","author":"Friedman M.","journal-title":"Laryngoscope 1993;"},{"key":"bibr9-030089169708300610","doi-asserted-by":"publisher","DOI":"10.1177\/019459989210600124"},{"key":"bibr10-030089169708300610","volume-title":"UICC TNM Classification of malignant tumors","author":"Hermanek P.","year":"1992","edition":"4"},{"key":"bibr11-030089169708300610","volume-title":"Harrison's principles of internal medicine","author":"Isselbacher K.J.","year":"1994","edition":"13"},{"key":"bibr12-030089169708300610","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1992.01880030025006"},{"issue":"8","key":"bibr13-030089169708300610","first-page":"432","volume":"250","author":"Lenz M.","journal-title":"Eur. 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