{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:10:24Z","timestamp":1791090624613,"version":"4.1.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1998,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and background<\/jats:title>\n                    <jats:p>The aim of this study was to compare the local immune response in two groups of patients with high-grade cervical intraepithelial squamous lesions (SIL): one with HIV infection and the other with HPV infection alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      16 conization specimens (8 from HIV-infected and 8 from non-HIV-infected patients) of HPV-related, high-grade SIL were selected. The specimens from non-HIV patients were considered as controls. The total number of Langerhans cells, CD4 and CD8 cells present in 10 field areas (3.120 mm\n                      <jats:sup>2<\/jats:sup>\n                      ) was recorded in each case. In HIV patients CD4 and CD8 peripheral counts were performed immediately before surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The CD4\/CD8 ratio never exceeded 0.71, whereas the lowest ratio in controls was 0.81: this difference was statistically significant (P=0.0009). The mean number of Langerhans cells was markedly reduced in the high-grade SILs in the HIV patients in comparison with controls (P=0.001). The number of CD4 cells and the CD4\/CD8 ratio correlated with the peripheral CD4 count (P=0.001 and 0.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In our study a marked local impairment of cervical immunoreactivity was observed, which may play a major role in the progression of these lesions in HIV-infected women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089169808400410","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:20:17Z","timestamp":1523881217000},"page":"489-492","source":"Crossref","is-referenced-by-count":12,"title":["Local Impairment of Immunoreactivity in Hiv-infected Women with Hpv-related Squamous Intraepithelial Lesions of the Cervix"],"prefix":"10.1177","volume":"84","author":[{"given":"Massimo C.","family":"Barberis","sequence":"first","affiliation":[{"name":"Diagnostic Laboratories, E. Bernardelli Foundation, Paderno Dugnano (MI)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Vago","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University of Milan, Ospedale L. Sacco, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Cecchini","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Ospedale Niguarda Ca\u2019 Granda, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Bramerio","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Ospedale Niguarda Ca\u2019 Granda, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Banfi","sequence":"additional","affiliation":[{"name":"Diagnostic Laboratories, E. Bernardelli Foundation, Paderno Dugnano (MI)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"D'Amico","sequence":"additional","affiliation":[{"name":"Diagnostic Laboratories, E. Bernardelli Foundation, Paderno Dugnano (MI)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Cannone","sequence":"additional","affiliation":[{"name":"Diagnostic Laboratories, E. Bernardelli Foundation, Paderno Dugnano (MI)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1998,7,1]]},"reference":[{"key":"bibr1-030089169808400410","first-page":"209","volume":"144","author":"Braun L.","year":"1994","journal-title":"Am. J. 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