{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:20:40Z","timestamp":1777918840490,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and Background<\/jats:title>\n                    <jats:p>Non-melanocytic skin cancers are the most common cancers in white populations. Studies on populations of Anglo-Saxon and Mediterranean origins highlighted different patterns of risk of basal-cell carcinoma and squamous-cell carcinoma in relation to sunlight exposure, skin characteristics and phenotype susceptibility. In Sion, and in Switzerland as a whole, the high incidence suggests the possible presence of additional risk factors or of a different pattern of exposure to solar radiation as well as different composition of pigmentary traits and skin sensitivity to sun.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Study Design<\/jats:title>\n                    <jats:p>We conducted a case-control study of 146 cases (73% of eligible cases) and 144 controls (81% of eligible subjects) to further evaluate the relationship between nonmelanocytic skin cancer and risk factors in the Sion population. Interviews were conducted by trained interviewers with a standardized questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pigmentary characteristics such as blonde and red hair as well as tendency to sunburn without tanning and number of sunburns showed a statistically significant and independent risk increase in basal-cell carcinoma. Sun exposure during recreational activities (outdoor sports) showed a risk increase in basal-cell carcinoma with borderline statistical significance. Analysis of squamous-cell carcinoma risk was limited by the small number of cases, but it was positively associated with lifetime exposure to sun during outdoor work and with skin characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results confirmed previous suggestions of a different mechanism leading to malignant transformation of target cells from the basal and squamous epidermal layers, mediated by different phenotypes, and conditioning the ability to develop an effectively protective tan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089169908500603","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:48:29Z","timestamp":1523944109000},"page":"435-442","source":"Crossref","is-referenced-by-count":44,"title":["Risk of Basal and Squamous Cell Carcinomas of the Skin in Sion, Switzerland: A Case-control Study"],"prefix":"10.1177","volume":"85","author":[{"given":"Stefano","family":"Rosso","sequence":"first","affiliation":[{"name":"CPO Registro Tumori Piemonte, Sion, Switzerland, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Joris","sequence":"additional","affiliation":[{"name":"Registre Valaisan des Tumeurs, Sion, Switzerland, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Zanetti","sequence":"additional","affiliation":[{"name":"CPO Registro Tumori Piemonte, Sion, Switzerland, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,11,1]]},"reference":[{"key":"bibr1-030089169908500603","first-page":"907","volume":"55","author":"Aubry F.","year":"1985","journal-title":"A case-control study in the Montreal region. Cancer"},{"key":"bibr2-030089169908500603","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb14171.x"},{"key":"bibr3-030089169908500603","first-page":"365","volume":"69","author":"Fears T.R.","year":"1982","journal-title":"J. Natl. Cancer Inst."},{"key":"bibr4-030089169908500603","doi-asserted-by":"publisher","DOI":"10.1007\/BF00054300"},{"key":"bibr5-030089169908500603","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690140041006"},{"key":"bibr6-030089169908500603","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690140048007"},{"key":"bibr7-030089169908500603","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910460303"},{"key":"bibr8-030089169908500603","doi-asserted-by":"publisher","DOI":"10.1016\/0923-1811(90)90222-Y"},{"key":"bibr9-030089169908500603","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(90)90015-K"},{"key":"bibr10-030089169908500603","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910480504"},{"key":"bibr11-030089169908500603","first-page":"489","volume":"60","author":"Kricker A.","year":"1995","journal-title":"A case-control study in Western Australia. Int. J. Cancer"},{"key":"bibr12-030089169908500603","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910600410"},{"key":"bibr13-030089169908500603","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.460"},{"key":"bibr14-030089169908500603","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910530410"},{"key":"bibr15-030089169908500603","volume-title":"Cancer incidence in five continents.","author":"Parkin D.M.","year":"1997"},{"key":"bibr16-030089169908500603","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.275"},{"key":"bibr17-030089169908500603","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900615)65:12<2811::AID-CNCR2820651234>3.0.CO;2-U"},{"key":"bibr18-030089169908500603","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.274"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169908500603","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169908500603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:47:49Z","timestamp":1777661269000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089169908500603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["10.1177\/030089169908500603"],"URL":"https:\/\/doi.org\/10.1177\/030089169908500603","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11]]}}}