{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:20:45Z","timestamp":1777918845084,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and Background<\/jats:title>\n                    <jats:p>A pilot study of neoadjuvant chemotherapy with cyclophosphamide-epirubicin-5-fluorouracil (FEC) was performed on 85 patients with locally advanced breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Study Design<\/jats:title>\n                    <jats:p>Patients received four cycles of neoadjuvant chemotherapy followed by surgery, radiotherapy and a treatment with cyclophosphamide-methotrexate-5-fluorouracil for three cycles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Major clinical response was obtained in 76 (89%) patients. Complete response was documented in 14 (17%) patients at pathologic examination of surgical specimen. Grade 1-2 nausea and vomiting was the most common (77%) side effect. Grade 2-3 alopecia was 66%. Grade 2-3 neutropenia occurred in 16% of patients. None of the patients developed febrile neutropenia. Sinus tachycardia was observed only in one patient. Three patients had a more than 10% decrease in the left ventricular ejection fraction without any clinical signs. Nine patients had progressive or stable disease and 4 did not undergo surgery or receive radiation therapy; thus 13 were excluded from survival analysis. After a median follow-up of 31 months (range, 15-41), disease-free survival and overall survival were 20 (range, 13-32) and 23 months (range, 17-32).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The FEC combination is safe and effective for a neoadjuvant setting in locally advanced breast cancer. A longer follow-up is necessary for the end point results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089169908500611","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:48:29Z","timestamp":1523944109000},"page":"483-487","source":"Crossref","is-referenced-by-count":5,"title":["Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer: A Preliminary Report"],"prefix":"10.1177","volume":"85","author":[{"given":"Esmen","family":"Baltali","sequence":"first","affiliation":[{"name":"Hacettepe University, Institute of Oncology, Department of Medical Oncology, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazan","family":"G\u00fcnel","sequence":"additional","affiliation":[{"name":"Gazi University Medical Faculty, Department of Medical Oncology, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demir Ali","family":"Onat","sequence":"additional","affiliation":[{"name":"Hacettepe University, Institute of Oncology, Department of Medical Oncology, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibdisan Lale","family":"Atahan","sequence":"additional","affiliation":[{"name":"Hacettepe University, Department of Radiation Oncology, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zafer","family":"Ak\u00e7ali","sequence":"additional","affiliation":[{"name":"Gazi University Medical Faculty, Department of Medical Oncology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evin","family":"B\u00fcy\u00fck\u00fcnal","sequence":"additional","affiliation":[{"name":"Cerrahpa\u015fa University Medical Faculty, Department of Medical Oncology, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dincer","family":"Firat","sequence":"additional","affiliation":[{"name":"Hacettepe University, Institute of Oncology, Department of Medical Oncology, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Turkish Oncology Study Group, Turkey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,11,1]]},"reference":[{"key":"bibr1-030089169908500611","volume-title":"Manual for Staging of Cancer.","author":"American Joint Committee on Cancer.","year":"1997","edition":"5"},{"key":"bibr2-030089169908500611","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1991.131"},{"key":"bibr3-030089169908500611","first-page":"58","volume":"27","author":"Baltaly E.","year":"1997","journal-title":"Turkish J. Cancer"},{"key":"bibr4-030089169908500611","first-page":"99","volume":"384","author":"Baltaly E.","year":"1992","journal-title":"Ann. Oncol., 3 (suppl), Abstr"},{"key":"bibr5-030089169908500611","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.1.207"},{"key":"bibr6-030089169908500611","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(95)00612-5"},{"key":"bibr7-030089169908500611","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.93"},{"key":"bibr8-030089169908500611","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520310040027"},{"key":"bibr9-030089169908500611","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(18)30426-5"},{"key":"bibr10-030089169908500611","first-page":"229","volume":"4","author":"De Lena M.","year":"1981","journal-title":"Results of chemotherapy-radiotherapy versus chemotherapy-surgery. Cancer Clin. Trials"},{"key":"bibr11-030089169908500611","first-page":"244","volume":"19","author":"Elledge R.M.","year":"1992","journal-title":"Semin. Oncol."},{"key":"bibr12-030089169908500611","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.7.2483"},{"key":"bibr13-030089169908500611","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900915)66:14+<1387::AID-CNCR2820661414>3.0.CO;2-I"},{"key":"bibr14-030089169908500611","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19881215)62:12<2507::AID-CNCR2820621210>3.0.CO;2-D"},{"key":"bibr15-030089169908500611","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880515)61:10<1977::AID-CNCR2820611008>3.0.CO;2-N"},{"key":"bibr16-030089169908500611","first-page":"64","volume":"11","author":"Negro A.","year":"1992","journal-title":"Proc. Am. Soc. Clin. Oncol."},{"key":"bibr17-030089169908500611","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.3.547"},{"key":"bibr18-030089169908500611","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(94)90537-1"},{"key":"bibr19-030089169908500611","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(93)90133-Z"},{"key":"bibr20-030089169908500611","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.2.424"},{"key":"bibr21-030089169908500611","doi-asserted-by":"publisher","DOI":"10.1007\/BF01806351"},{"key":"bibr22-030089169908500611","unstructured":"WHO Handbook for Reporting Results of Cancer Treatment. Geneva, World Health Organization (WHO Offset Publication No. 48), pp. 16\u201327, 1979."}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169908500611","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089169908500611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:47:52Z","timestamp":1777661272000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089169908500611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["10.1177\/030089169908500611"],"URL":"https:\/\/doi.org\/10.1177\/030089169908500611","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11]]}}}