{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:25Z","timestamp":1787018785001,"version":"build-2736575974"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>Congenital hepatic fibrosis is a disorder of biliary system development histologically characterized by diffuse periportal to bridging fibrosis with numerous small often-irregular bile ducts and reduction in the number of portal vein branches. The condition results from abnormal development of the ductal plate, the embryonic precursor to the interlobular bile ducts. It has rarely been reported in veterinary species, and it has never been reported in dogs. This article describes 5 cases of a ductal plate malformation in dogs consistent with congenital hepatic fibrosis. On light microscopy, all 5 livers had severe bridging fibrosis with a marked increase in the number of small bile ducts, which often had irregular, dilated profiles reminiscent of the developing ductal plate. In addition, 80% (4 of 5) of cases lacked typical portal vein profiles. Cytokeratin 7 and proliferating cell nuclear antigen immunohistochemistry was performed on the 3 cases for which paraffin-embedded tissue was available. The bile duct profiles were strongly positive for cytokeratin 7 in all 3 cases, and they were negative for proliferating cell nuclear antigen or only had rare positive cells. All 5 dogs presented with clinical signs of portal hypertension. Congenital hepatic fibrosis should be considered in the differential diagnosis in young dogs that present with portal hypertension and lesions that may have been interpreted as bridging biliary hyperplasia or extrahepatic biliary obstruction.<\/jats:p>","DOI":"10.1177\/0300985809353313","type":"journal-article","created":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T17:16:15Z","timestamp":1268068575000},"page":"102-107","source":"Crossref","is-referenced-by-count":34,"title":["Congenital Hepatic Fibrosis in 5 Dogs"],"prefix":"10.1177","volume":"47","author":[{"given":"D. L.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Van Winkle","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology and Toxicology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Cecere","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rushton","sequence":"additional","affiliation":[{"name":"Rollins Diagnostic Laboratory, Raleigh, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Brachelente","sequence":"additional","affiliation":[{"name":"Department of Biopathological Sciences and Hygiene of Animal and Food Production, University of Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Cullen","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,1,1]]},"reference":[{"key":"bibr1-0300985809353313","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2004.01945.x"},{"key":"bibr2-0300985809353313","first-page":"145","volume":"42","author":"Bourque AC","year":"2001","journal-title":"Can Vet J"},{"key":"bibr3-0300985809353313","doi-asserted-by":"publisher","DOI":"10.1354\/vp.44-1-100"},{"key":"bibr4-0300985809353313","first-page":"45","volume-title":"WSAVA Standards for Clinical and Histological Diagnosis of Canine and Feline Liver Disease","author":"Cullen JM","year":"2006"},{"key":"bibr5-0300985809353313","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)63624-0"},{"key":"bibr6-0300985809353313","doi-asserted-by":"crossref","unstructured":"Desmet V: What is congenital hepatic fibrosis? 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