{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:21:14Z","timestamp":1777918874660,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,12,31]],"date-time":"2009-12-31T00:00:00Z","timestamp":1262217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p>C hepatica, an important zoonotic parasite, and C fasciolaris are common parasites in rodents. In rodent livers, C hepatica causes sequential morphologic changes that are designated as early, intermediate, or late phase, and C fasciolaris forms cysts surrounded by fibroplasia and granulomatous inflammation. The present study describes the prevalence of these parasites and associated liver and lung lesions in wild rats ( Rattus norvegicus) living around pig farms in South Korea. Selected parenchymal organs, including liver and lung, of 89 wild rats were examined. Of 89 rats, 28 (31.5%) were infected with either C hepatica or C fasciolaris or with both parasites. Severe medial hypertrophy of small arterioles was observed in the lungs of 11 of the 28 parasite-infected rats ( P &lt; .01). The pulmonary arteriolar hypertrophy in the rats infected with C hepatica was strongly associated with early and\/or intermediate phases (88.8%) of morphologic change in the livers ( P &lt; .01). As such, this report is the first to suggest a significant association between parasite-induced hepatitis and pulmonary arteriolar hypertrophy in rodents. Further studies are warranted for the use of C hepatica\u2013infected rats as an animal model to explore the underlying mechanisms of portopulmonary hypertension in humans.<\/jats:p>","DOI":"10.1177\/0300985809359306","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T23:00:25Z","timestamp":1264806025000},"page":"292-297","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of Hepatic Parasites in Korean Wild Rats (\n                    <i>Rattus norvegicus<\/i>\n                    ) and Their Association With Pulmonary Arteriolar Medial Hypertrophy"],"prefix":"10.1177","volume":"47","author":[{"given":"J.-Y.","family":"Yi","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea"},{"name":"Current address: Medical Device Research Division, National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.-H.","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.-C.","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.-W.","family":"Hahn","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Jeong","sequence":"additional","affiliation":[{"name":"Dodram Pig Farmer\u2019s Cooperative Pig Research Center, Icheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.-U.","family":"Choi","sequence":"additional","affiliation":[{"name":"National Veterinary Research and Quarantine Service, Anyang, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.-H.","family":"Woo","sequence":"additional","affiliation":[{"name":"National Veterinary Research and Quarantine Service, Anyang, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.-B.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-H.","family":"Han","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.-I.","family":"Yoon","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea"},{"name":"Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,12,31]]},"reference":[{"key":"bibr1-0300985809359306","first-page":"1","volume":"5","author":"Alpert JS","year":"1981","journal-title":"Dis Mon"},{"key":"bibr2-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762004000400010"},{"key":"bibr3-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/79.1.127"},{"key":"bibr4-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1007\/BF02171560"},{"key":"bibr5-0300985809359306","first-page":"267","volume":"31","author":"Bhattacharya D","year":"1999","journal-title":"J Commun Dis"},{"key":"bibr6-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0450.2001.00436.x"},{"key":"bibr7-0300985809359306","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1993.48.610"},{"key":"bibr8-0300985809359306","first-page":"393","volume-title":"Pathologic Basis of Veterinary Disease","author":"Cullen JM","year":"2007","edition":"4"},{"key":"bibr9-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80123-7"},{"key":"bibr10-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.2.161"},{"key":"bibr11-0300985809359306","first-page":"359","volume-title":"Parasitology for Veterinarians","author":"Georgi JR","year":"1990","edition":"5"},{"key":"bibr12-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762006000800012"},{"key":"bibr13-0300985809359306","doi-asserted-by":"publisher","DOI":"10.2307\/3285682"},{"key":"bibr14-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1177\/030098589503200418"},{"key":"bibr15-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16107-2"},{"key":"bibr16-0300985809359306","first-page":"1030","volume":"52","author":"Huffmyer JL","year":"2007","journal-title":"Respir Care"},{"key":"bibr17-0300985809359306","first-page":"697","volume-title":"Pathologic Basis of Disease","author":"Kobzik L","year":"1999","edition":"6"},{"key":"bibr18-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1136\/vr.151.14.419"},{"key":"bibr19-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(05)70296-3"},{"key":"bibr20-0300985809359306","first-page":"92","volume-title":"Parasitology in Focus: Facts and Trends","author":"Mehlhorn H","year":"1998"},{"key":"bibr21-0300985809359306","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.1979.17.2.93"},{"key":"bibr22-0300985809359306","first-page":"781","volume":"44","author":"Nabi F","year":"2007","journal-title":"Indian Pediatr"},{"issue":"1","key":"bibr23-0300985809359306","first-page":"179","volume":"28","author":"Namue C","year":"1997","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"bibr24-0300985809359306","first-page":"238","volume":"12","author":"Okaeme AN","year":"1985","journal-title":"Int J Zoonoses"},{"key":"bibr25-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762001000700020"},{"key":"bibr26-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(05)70305-1"},{"key":"bibr27-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1136\/vr.164.2.66"},{"key":"bibr28-0300985809359306","first-page":"40","volume":"29","author":"Ratti L","year":"2006","journal-title":"Gastroenterol Hepatol"},{"key":"bibr29-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1378\/chest.85.3.397"},{"key":"bibr30-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822001000600001"},{"key":"bibr31-0300985809359306","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.61.642"},{"key":"bibr32-0300985809359306","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.1995.33.3.235"},{"key":"bibr33-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00005897"},{"key":"bibr34-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2000001100011"},{"key":"bibr35-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2006.07.004"},{"key":"bibr36-0300985809359306","first-page":"401","volume":"23","author":"Tucek PC","year":"1973","journal-title":"Lab Anim Sci"},{"key":"bibr37-0300985809359306","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.71.43"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985809359306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985809359306","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985809359306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:48:42Z","timestamp":1777661322000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985809359306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,31]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1177\/0300985809359306"],"URL":"https:\/\/doi.org\/10.1177\/0300985809359306","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,31]]}}}