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In 38 hearts, the tumor was solitary; the remaining 6 hearts had multiple masses. All tumors were subendocardial and involved the papillary muscles and\/or cardiac valves. Two histologic patterns were recognized; both included giant cells. Pattern 1 was characterized by interlacing fascicles of spindle-shaped cells; pattern 2 resembled cavernous hemangioma. The 2 patterns coexisted and were linked by transitional zones. Given the immunohistochemical reactivity and ultrastructure, the spindle-shaped cells were identified as smooth muscle cells and the giant cells as endothelial cells. Single cell and multicellular angiogenesis by giant cells was observed. The tumors were classified as cardiac angioleiomyoma. Subendocardial multipotential mesenchymal cells, persistent tissue of the endocardial cushion, or valvular interstitial cells were suspected as the origin.<\/jats:p>","DOI":"10.1177\/0300985810375055","type":"journal-article","created":{"date-parts":[[2010,6,23]],"date-time":"2010-06-23T23:15:29Z","timestamp":1277334929000},"page":"923-930","source":"Crossref","is-referenced-by-count":12,"title":["Cardiac Angioleiomyoma in 44 Cattle in Japan (1982\u20132009)"],"prefix":"10.1177","volume":"47","author":[{"given":"Y.","family":"Une","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Shirota","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, 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