{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:26Z","timestamp":1787018786569,"version":"build-2736575974"},"reference-count":10,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2010,11,29]],"date-time":"2010-11-29T00:00:00Z","timestamp":1290988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>Hepatoblastomas are neoplasms that originate from putative pluripotential stem cells of the liver. A hepatic mass from an 8-year-old Abyssinian cat was composed of cords and sheets of neoplastic cells, with scattered rosettes and small ductal structures. Most neoplastic cells had a pale eosinophilic cytoplasm and a round to ovoid nucleus. The tumor also had short spindle cells with an oval nucleus. Immunohistochemically, neoplastic cells were weakly positive for embryonic hepatocellular markers, such as alpha-fetoprotein and cytokeratin (CK) 8\/18, but negative for the hepatocellular marker Hepatocyte Paraffin 1. The cells were also positive for CD56\/neural cell adhesion molecule and for the biliary epithelial markers CK 7, CK 8\/18, CK CAM5.2, and vimentin, but negative for CK 20. Some neoplastic cells expressed neuroectodermal or neuroendocrine markers, such as protein gene product 9.5 and synaptophysin, but were negative for chromogranin A and not argyrophilic by the Grimelius technique. The cat died soon after the biopsy without clinical improvement.<\/jats:p>","DOI":"10.1177\/0300985810390017","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T20:13:54Z","timestamp":1291148034000},"page":"1020-1023","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Hepatoblastoma in a Cat"],"prefix":"10.1177","volume":"48","author":[{"given":"N.","family":"Ano","sequence":"first","affiliation":[{"name":"Marupi Lifetech Co, Ltd, Ikeda, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Setsunan University, Hirakata, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Nomura","sequence":"additional","affiliation":[{"name":"Marupi Lifetech Co, Ltd, Ikeda, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Narama","sequence":"additional","affiliation":[{"name":"Setsunan University, Hirakata, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,11,29]]},"reference":[{"key":"bibr1-0300985810390017","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80219-8"},{"key":"bibr2-0300985810390017","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.4A6297.2004"},{"key":"bibr3-0300985810390017","unstructured":"Head K, Cullen JM, Dubielzig R, Else R, Misdorp W, Patnaik AK, Tateyama S, van der Gaag I: Histological Classification of Tumors of the American System of Domestic Animals. 2nd ed. vol. 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