{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:22:26Z","timestamp":1777918946289,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>\n                    The distribution pattern and associated tissue reactions with progressive changes in Besnoitia caprae cysts were investigated in 6 experimentally infected 16- to 20-month-old male goats. Each goat was subcutaneously inoculated with approximately 13 \u00d7 10\n                    <jats:sup>8<\/jats:sup>\n                    B caprae bradyzoites. The animals were examined daily for development of clinical besnoitiosis, and skin biopsies from distal parts of the limbs were taken at weekly intervals. At 15, 30, 60, 120, 180, and 365 days postinfection (DPI), 1 goat was euthanized. Samples were collected at autopsy from various organs for histologic and ultrastructural studies. No cysts were seen in tissue sections on 15, 30, and 365 DPI, but large numbers were present at 60, 120, and 180 DPI in the skin of the distal limbs, scrotum, and ears, with fewer in the tongue, palate, sclera, testicles, and spermatic cord. No cysts were seen in the lungs, liver, kidneys, spleen, central nervous system, or lymph nodes. Cyst numbers peaked at 60 DPI, then declined from 120 to 180 DPI. Degenerated cysts were relatively rare at 60 DPI but more numerous at 180 compared with 120. A granulomatous reaction\u2014predominantly characterized by macrophages, lymphocytes, and plasma cells\u2014surrounded each degenerated cyst. All goats showed testicular tubular degeneration with little or no spermatogenic activity. The sizes of cysts and their wall thickness, with the size of bradyzoites and some of their organelles, exhibited progressive chronologic changes.\n                  <\/jats:p>","DOI":"10.1177\/0300985811398248","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T23:05:08Z","timestamp":1296601508000},"page":"1094-1100","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Histopathologic and Ultrastructural Studies on Experimental Caprine Besnoitiosis"],"prefix":"10.1177","volume":"48","author":[{"given":"A.","family":"Oryan","sequence":"first","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Namazi","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. A.","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Veterinary Science, Bristol, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,2,1]]},"reference":[{"key":"bibr1-0300985811398248","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-31.3.319"},{"key":"bibr2-0300985811398248","first-page":"3","volume":"35","author":"Bigalke RD","year":"1968","journal-title":"Onderstepoort J Vet Res"},{"key":"bibr3-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1136\/vr.125.18.461"},{"key":"bibr4-0300985811398248","first-page":"23","volume":"24","author":"Bwangamoi O","year":"1993","journal-title":"Zimbabwe Vet J"},{"key":"bibr5-0300985811398248","first-page":"24","volume":"127","author":"Castillo JA","year":"2009","journal-title":"Albeitar"},{"key":"bibr6-0300985811398248","first-page":"159","volume":"69","author":"Cheema AH","year":"1979","journal-title":"Cornell Vet"},{"key":"bibr7-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1136\/vr.157.9.262"},{"key":"bibr8-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1007\/BF00932710"},{"key":"bibr9-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2005.01.004"},{"key":"bibr10-0300985811398248","first-page":"521","volume":"126","author":"Dubey JP","year":"2003","journal-title":"Parasitol"},{"key":"bibr11-0300985811398248","first-page":"329","volume":"151","author":"Ellis JT","year":"2000","journal-title":"Protistologica"},{"key":"bibr12-0300985811398248","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-26.2.186"},{"key":"bibr13-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-006-0662-y"},{"key":"bibr14-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(81)90037-6"},{"key":"bibr15-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(93)90074-W"},{"key":"bibr16-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-008-1267-y"},{"key":"bibr17-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(94)90111-2"},{"key":"bibr18-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(94)90112-0"},{"key":"bibr19-0300985811398248","first-page":"133","volume":"65","author":"Njagi ON","year":"1998","journal-title":"Onderstepoort J Vet Res"},{"key":"bibr20-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1007\/BF01839312"},{"key":"bibr21-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1007\/BF01839168"},{"key":"bibr22-0300985811398248","doi-asserted-by":"publisher","DOI":"10.4102\/jsava.v70i4.784"},{"key":"bibr23-0300985811398248","doi-asserted-by":"publisher","DOI":"10.4102\/jsava.v70i1.745"},{"key":"bibr24-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-008-0890-y"},{"key":"bibr25-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-007-0717-8"},{"key":"bibr26-0300985811398248","first-page":"27","volume":"159","author":"Oryan A","year":"2008","journal-title":"Rev Med Vet"},{"key":"bibr27-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005918931296"},{"key":"bibr28-0300985811398248","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(02)00156-5"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985811398248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985811398248","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985811398248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:50:34Z","timestamp":1777661434000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985811398248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,1]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1177\/0300985811398248"],"URL":"https:\/\/doi.org\/10.1177\/0300985811398248","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,1]]}}}