{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:02:30Z","timestamp":1790611350859,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>Immunohistochemistry for E-cadherin (ECAD) has been used to distinguish canine cutaneous histiocytoma from other leukocytic neoplasms (\u201cround cell tumors\u201d). To determine the specificity of this test, 5 types of canine cutaneous round cell tumors were evaluated for immunohistochemical expression of ECAD. Tumors of all 5 types had variable cytoplasmic, plasma membrane, and\/or paranuclear ECAD expression: All 13 cutaneous histiocytomas were ECAD+; all but 1 of 14 mast cell tumors expressed ECAD; 10 of 12 epitheliotropic lymphomas reacted with E-cadherin antibody; of 72 plasmacytomas, 54 were ECAD+; and 5 of 5 histiocytic sarcomas were positive. Conclusions based on these results include the following: First, immunoreactivity for ECAD is not limited to leukocytes of cutaneous histiocytoma; second, antibody to ECAD also labels neoplastic cells in most mast cell tumors, plasmacytomas, cutaneous histiocytic sarcomas, and epitheliotropic lymphomas; third, although most histiocytomas have membranous ECAD expression, the immunoreactivity varies among round cell tumors and is frequently concurrent in different cellular compartments; fourth, the distinctively paranuclear ECAD expression pattern in epitheliotropic lymphomas might distinguish them from other round cell tumors; and, fifth, ECAD should be used with other markers (eg, MUM1 for plasmacytomas, KIT for mast cell tumors, CD3 and CD79a for lymphomas) to distinguish among canine round cell tumors.<\/jats:p>","DOI":"10.1177\/0300985811398251","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T23:05:08Z","timestamp":1296601508000},"page":"758-763","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Immunohistochemical Expression of E-cadherin Does Not Distinguish Canine Cutaneous Histiocytoma From Other Canine Round Cell Tumors"],"prefix":"10.1177","volume":"48","author":[{"given":"J. A.","family":"Ramos-Vara","sequence":"first","affiliation":[{"name":"Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,2,1]]},"reference":[{"key":"bibr1-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12320959"},{"key":"bibr2-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.131.1.243"},{"key":"bibr3-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1996.266305.x"},{"key":"bibr4-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1136\/vr.162.16.509"},{"key":"bibr5-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(92)90283-E"},{"key":"bibr6-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e31817bf566"},{"key":"bibr7-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31813547f8"},{"key":"bibr8-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.036715"},{"key":"bibr9-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01171.x"},{"key":"bibr10-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00768.x"},{"key":"bibr11-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1177\/42.10.7930515"},{"key":"bibr12-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00475.x"},{"key":"bibr13-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1016\/S1000-1948(09)60018-6"},{"key":"bibr14-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.10.3208"},{"key":"bibr15-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2003.apm1111109.x"},{"key":"bibr16-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1177\/030098588402100503"},{"key":"bibr17-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1136\/vr.163.2.59-a"},{"key":"bibr18-0300985811398251","first-page":"2713","volume":"29","author":"Pires I","year":"2009","journal-title":"Anticancer Res"},{"key":"bibr19-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1354\/vp.42-4-405"},{"key":"bibr20-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1177\/104063870001200402"},{"key":"bibr21-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1354\/vp.44-1-74"},{"key":"bibr22-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810364528"},{"key":"bibr23-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1354\/vp.44-6-875"},{"key":"bibr24-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.12.062"},{"key":"bibr25-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20295"},{"key":"bibr26-0300985811398251","first-page":"2128","volume":"49","author":"Shimoyama Y","year":"1989","journal-title":"Cancer Res"},{"key":"bibr27-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.27.1891"},{"key":"bibr28-0300985811398251","first-page":"2027","volume":"24","author":"Syrigos KN","year":"2004","journal-title":"Anticancer Res"},{"key":"bibr29-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2005.apm1130202.x"},{"key":"bibr30-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780167"},{"issue":"1","key":"bibr31-0300985811398251","first-page":"6","volume":"107","author":"Udey MC","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"bibr32-0300985811398251","unstructured":"Valli VE, Jacobs RM, Parodi AL, Vernau W, Moore PF: Histological Classification of Hematopoietic Tumors of Domestic Animals, 2nd ed. Armed Forces Institute of Pathology, Washington, DC, 2002."},{"key":"bibr33-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.5.3328"},{"key":"bibr34-0300985811398251","first-page":"524","volume":"102","author":"Wayner EA","year":"1994","journal-title":"J Invest Dermatol"},{"key":"bibr35-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1354\/vp.41-4-371"},{"key":"bibr36-0300985811398251","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2009.01146.x"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985811398251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985811398251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985811398251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:50:36Z","timestamp":1777661436000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985811398251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,1]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1177\/0300985811398251"],"URL":"https:\/\/doi.org\/10.1177\/0300985811398251","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,1]]}}}