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Six affected aborted or stillborn calves were homozygous for the recently characterized deletion mutation in SLC4A2. Four affected calves were heterozygous for the SLC4A2 mutation and survived 1 to 7 days after birth. Gross lesions were similar in all 10 calves. Brains were rectangular and dorsoventrally compressed, with concave depressions in the parietal cortex owing to thickened parietal bone. Cerebellar hemispheres were compressed with herniation of the cerebellar vermis into the foramen magnum. Moderate bilateral chromatolysis affected multiple cranial nerve nuclei and, in some calves, the red nucleus. There was loss of retinal ganglion cells with severe atrophy of optic nerves. Periventricular corpora amylacea were in the thalamus, caudate nucleus, and midbrain. Vessels and neuropil in the dorsomedial aspect of the thalamus were mineralized. Dysplastic change in premolar and molar teeth comprised intra-alveolar intermingling of dentin, enamel, cementum, and bone, contributing to dental ankylosis. Changes in the heads of osteopetrotic calves are similar to those in children with malignant forms of homozygous recessive osteopetrosis.<\/jats:p>","DOI":"10.1177\/0300985811412621","type":"journal-article","created":{"date-parts":[[2011,7,19]],"date-time":"2011-07-19T01:12:24Z","timestamp":1311037944000},"page":"746-754","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Neuropathology and Craniofacial Lesions of Osteopetrotic Red Angus Calves"],"prefix":"10.1177","volume":"49","author":[{"given":"D.","family":"O\u2019Toole","sequence":"first","affiliation":[{"name":"Wyoming State Veterinary Laboratory, Department of Veterinary Sciences, University of Wyoming, Laramie, Wyoming"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Swist","sequence":"additional","affiliation":[{"name":"Wyoming State Veterinary Laboratory, Department of Veterinary Sciences, University of Wyoming, Laramie, Wyoming"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Steadman","sequence":"additional","affiliation":[{"name":"Chadron Veterinary Clinic, Chadron, Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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