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At necropsy, severe bilateral guttural pouch empyema was observed, as well as numerous well-demarcated areas of pallor within the skeletal muscles of all major muscle groups. Polymerase chain reaction testing of the guttural pouch exudate confirmed an infection with Streptococcus equi subsp. equi, and an S. equi\u2013associated immune-mediated rhabdomyolysis was initially considered to be the most likely diagnosis. This report briefly discusses the various etiologies that should be considered in cases of equine myopathy, and it demonstrates the complexity of these poorly understood muscular disorders.<\/jats:p>","DOI":"10.1177\/0300985811414034","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T00:26:03Z","timestamp":1312244763000},"page":"E52-E59","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Diagnostic Exercise: Equine Rhabdomyolysis"],"prefix":"10.1177","volume":"48","author":[{"given":"E. M.","family":"Quist","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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