{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:22:47Z","timestamp":1777918967436,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T00:00:00Z","timestamp":1320883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Borrelia burgdorferi is the causative agent of Lyme disease, which is mainly characterized by lameness in dogs. More than 95% of naturally infected dogs are asymptomatic or subclinical; however, in experimental studies, histologic synovial lesions are consistently observed in asymptomatic dogs inoculated with B. burdgorferi. This study investigates the ability of a synovial histopathologic scoring system, clinicopathologic data, and polymerase chain reaction (PCR) testing to differentiate between B. burgdorferi\u2013infected and uninfected dogs. Eighteen 18-week-old beagles were subject to challenge with B. burgdorferi\u2013infected wild-caught ticks ( Ixodes scapularis), and 4 uninfected dogs served as controls. Infection was confirmed by serology (ELISA) and PCR amplification of B. burgdorferi\u2013specific DNA of skin biopsies taken at the tick attachment site. A synovial scoring system from human medicine was adapted and implemented on postmortem synovial samples to discriminate infected and noninfected animals. Application of this system to elbows and stifles with a cumulative joint score cutoff \u00a0&gt; 4 showed a sensitivity of 88.2% and a specificity of 100%, with a positive likelihood ratio of infinity and a negative likelihood ratio of 0.12. Complete blood count, serum biochemistry, urinalysis, urine protein:creatinine, urine PCR, synovial and lymph node cytology, and synovial PCR were evaluated but were not reliable indicators of clinical disease.<\/jats:p>","DOI":"10.1177\/0300985811424754","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T01:58:10Z","timestamp":1320976690000},"page":"453-461","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Synovial Lesions in Experimental Canine Lyme Borreliosis"],"prefix":"10.1177","volume":"49","author":[{"given":"L.","family":"Susta","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Department of Pathology, University of Georgia, Athens, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. W.","family":"Uhl","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Department of Pathology, University of Georgia, Athens, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Grosenbaugh","sequence":"additional","affiliation":[{"name":"Merial Limited, Athens, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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