{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:22:52Z","timestamp":1777918972938,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T00:00:00Z","timestamp":1324252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>Amanitin is a toxic cyclopeptide present in several species of poisonous mushrooms. Amanitin toxicosis was diagnosed in 2 cats from separate premises. Both cats initially had lethargy and vomiting, and they rapidly developed depression and neurological signs over 24\u201348 hours. Marked elevation of alanine aminotransferase was the primary finding, with subsequent serum chemistry values compatible with hepatic and renal failure. Histopathological findings consisted of submassive to massive acute hepatic necrosis, renal proximal tubular epithelial necrosis, and foci of necrosis and inflammation in the gastrointestinal tract. Amanitin exposure was confirmed postmortem by detection of \u03b1-amanitin in the kidney by liquid chromatography\u2013mass spectrometry. A similar clinical course and pathological changes are reported in human and canine amanitin intoxication; however, gastrointestinal lesions are not typically described.<\/jats:p>","DOI":"10.1177\/0300985811429307","type":"journal-article","created":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T23:19:30Z","timestamp":1324336770000},"page":"1032-1035","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Amanitin Toxicosis in Two Cats with Acute Hepatic and Renal Failure"],"prefix":"10.1177","volume":"49","author":[{"given":"D.","family":"Tokarz","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, University of California, Davis, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Poppenga","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, Davis, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kaae","sequence":"additional","affiliation":[{"name":"Pet Emergency and Specialty Center of Marin, San Rafael, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Filigenzi","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, Davis, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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