{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:23:11Z","timestamp":1777918991957,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T00:00:00Z","timestamp":1332460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>Genital Alphapapillomavirus (\u03b1PV) infections are one of the most common sexually transmitted human infections worldwide. Women infected with the highly oncogenic genital human papillomavirus (HPV) types 16 and 18 are at high risk for development of cervical cancer. Related oncogenic \u03b1PVs exist in rhesus and cynomolgus macaques. Here the authors identified 3 novel genital \u03b1PV types (PhPV1, PhPV2, PhPV3) by PCR in cervical samples from 6 of 15 (40%) wild-caught female Kenyan olive baboons ( Papio hamadryas anubis). Eleven baboons had koilocytes in the cervix and vagina. Three baboons had dysplastic proliferative changes consistent with cervical squamous intraepithelial neoplasia (CIN). In 2 baboons with PCR-confirmed PhPV1, 1 had moderate (CIN2, n = 1) and 1 had low-grade (CIN1, n = 1) dysplasia. In 2 baboons with PCR-confirmed PhPV2, 1 had low-grade (CIN1, n = 1) dysplasia and the other had only koilocytes. Two baboons with PCR-confirmed PhPV3 had koilocytes only. PhPV1 and PhPV2 were closely related to oncogenic macaque and human \u03b1PVs. These findings suggest that \u03b1PV-infected baboons may be useful animal models for the pathogenesis, treatment, and prophylaxis of genital \u03b1PV neoplasia. Additionally, this discovery suggests that genital \u03b1PVs with oncogenic potential may infect a wider spectrum of non-human primate species than previously thought.<\/jats:p>","DOI":"10.1177\/0300985812439725","type":"journal-article","created":{"date-parts":[[2012,3,24]],"date-time":"2012-03-24T03:46:35Z","timestamp":1332560795000},"page":"200-208","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Novel Genital\n                    <i>Alphapapillomaviruses<\/i>\n                    in Baboons (\n                    <i>Papio hamadryas Anubis<\/i>\n                    ) With Cervical Dysplasia"],"prefix":"10.1177","volume":"50","author":[{"given":"I. L.","family":"Bergin","sequence":"first","affiliation":[{"name":"Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Chen","sequence":"additional","affiliation":[{"name":"Dept of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA"},{"name":"Departments of Pediatrics, Microbiology & Immunology, Epidemiology & Population Health, and Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. K.","family":"Zochowski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Chai","sequence":"additional","affiliation":[{"name":"Institute of Primate Research, National Museums of Kenya, Nairobi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. L.","family":"Culmer","sequence":"additional","affiliation":[{"name":"Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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