{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:08:28Z","timestamp":1788538108254,"version":"build-2803163510"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T00:00:00Z","timestamp":1339977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>The clinical, clinicopathologic, and pathological findings of 9 dogs with T-cell lymphoma that involved the liver in the absence of peripheral lymphadenopathy were assessed. Seven dogs had hepatosplenic T-cell lymphoma (HS-TCL). Dogs with HS-TCL presented with hepato- and\/or splenomegaly, regenerative anemia, thrombocytopenia, and hypoproteinemia. The clinical course was rapidly progressive with all dogs but 1 dead within 24 days of initial presentation. Neoplastic lymphocytes were centered on hepatic and splenic sinusoids and had a CD3+ (5\/7), TCR\u03b1\u03b2\u2013 (5\/5), TCR\u03b3\u03b4+ (3\/5), CD11d+ (6\/7), granzyme B+ (5\/7) immunophenotype. Bone marrow and lungs were consistently but variably involved. These findings closely resemble the human disease and support the classification of HS-TCL as a distinct World Health Organization entity in dogs. The remaining 2 dogs markedly differed in the pattern of hepatic involvement by neoplastic lymphocytes, which were not confined to hepatic sinusoids but invaded hepatic cords. In addition, neoplastic cells had a CD11d\u2013 immunophenotype, and clinicopathologic data indicated marked cholestasis and mild to absent anemia. Based on the distinct tropism of neoplastic lymphocytes for hepatocytes, the name hepatocytotropic T-cell lymphoma (HC-TCL) is proposed. Given the histomorphologic, clinicopathologic, and immunophenotypic differences, HC-TCL likely represents a separate biological entity rather than a histomorphologic variant of HS-TCL.<\/jats:p>","DOI":"10.1177\/0300985812451625","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T22:51:04Z","timestamp":1340059864000},"page":"281-290","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":82,"title":["Hepatosplenic and Hepatocytotropic T-Cell Lymphoma"],"prefix":"10.1177","volume":"50","author":[{"given":"S. M.","family":"Keller","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Vernau","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hodges","sequence":"additional","affiliation":[{"name":"Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. H.","family":"Kass","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"Vilches-Moure","sequence":"additional","affiliation":[{"name":"Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"McElliot","sequence":"additional","affiliation":[{"name":"Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. F.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,6,18]]},"reference":[{"key":"bibr1-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1675"},{"key":"bibr2-0300985812451625","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804333"},{"key":"bibr3-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2004.tb00357.x"},{"key":"bibr4-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.11.4265.bloodjournal88114265"},{"key":"bibr5-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00893.x"},{"key":"bibr6-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1354\/vp.40-5-556"},{"key":"bibr7-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22034"},{"key":"bibr8-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02528-08"},{"key":"bibr9-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.975"},{"key":"bibr10-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1956.tb06700.x"},{"key":"bibr11-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2011.12.019"},{"key":"bibr12-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2011.12.008"},{"key":"bibr13-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.05.008"},{"key":"bibr14-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-6-637"},{"key":"bibr15-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1177\/030098588902600315"},{"key":"bibr16-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90176-3"},{"key":"bibr17-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2010.10.005"},{"key":"bibr18-0300985812451625","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"bibr19-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810379428"},{"key":"bibr20-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2797"},{"key":"bibr21-0300985812451625","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401784"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985812451625","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985812451625","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985812451625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:52:28Z","timestamp":1777661548000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985812451625"}},"subtitle":["Two Distinct Types of T-Cell Lymphoma in Dogs"],"short-title":[],"issued":{"date-parts":[[2012,6,18]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1177\/0300985812451625"],"URL":"https:\/\/doi.org\/10.1177\/0300985812451625","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,18]]}}}