{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:27:21Z","timestamp":1781188041097,"version":"3.54.1"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T00:00:00Z","timestamp":1356480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>\n                    H-type bovine spongiform encephalopathy (BSE) has been identified in aged cattle in Europe and North America. To determine the localization of disease-associated prion protein (PrP\n                    <jats:sup>Sc<\/jats:sup>\n                    ) in the peripheral nerve tissues of cattle affected with H-type BSE, we employed highly sensitive immunohistochemical and immunofluorescence techniques with the tyramide signal amplification (TSA) system. PrP\n                    <jats:sup>Sc<\/jats:sup>\n                    deposition was detected in the inferior ganglia, sympathetic nerve trunk, vagus nerve, spinal nerves, cauda equina, and adrenal medulla, using this system. Notably, granular PrP\n                    <jats:sup>Sc<\/jats:sup>\n                    deposits were present mainly in the Schwann cells and fibroblast-like cells and occasionally along certain nerve fibers at the surface of the axons. In the adrenal gland, PrP\n                    <jats:sup>Sc<\/jats:sup>\n                    immunolabeling was observed within the sympathetic nerve fibers and nerve endings in the adrenal medulla. Although our results were limited to only 3 experimental cases, these results suggest that the TSA system, a highly sensitive immunohistochemical procedure, may help in elucidating the peripheral pathogenesis of H-type BSE.\n                  <\/jats:p>","DOI":"10.1177\/0300985812471541","type":"journal-article","created":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T21:45:07Z","timestamp":1356558307000},"page":"659-663","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Immunohistochemical Detection of Disease-Associated Prion Protein in the Peripheral Nervous System in Experimental H-Type Bovine Spongiform Encephalopathy"],"prefix":"10.1177","volume":"50","author":[{"given":"H.","family":"Okada","sequence":"first","affiliation":[{"name":"Prion Disease Research Center, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Iwamaru","sequence":"additional","affiliation":[{"name":"Prion Disease Research Center, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Prion Disease Research Center, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mohri","sequence":"additional","affiliation":[{"name":"Prion Disease Research Center, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,12,26]]},"reference":[{"key":"bibr1-0300985812471541","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.5.747"},{"key":"bibr2-0300985812471541","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.5.2434-2439.2002"},{"key":"bibr3-0300985812471541","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(00)00364-6"},{"key":"bibr4-0300985812471541","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051108"},{"key":"bibr5-0300985812471541","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051109"},{"key":"bibr6-0300985812471541","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15487-1"},{"key":"bibr7-0300985812471541","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2001.0476"},{"key":"bibr8-0300985812471541","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-003-0524-5"},{"key":"bibr9-0300985812471541","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9716-42-79"},{"key":"bibr10-0300985812471541","doi-asserted-by":"publisher","DOI":"10.1086\/381166"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985812471541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985812471541","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985812471541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:53:01Z","timestamp":1777661581000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985812471541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,26]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1177\/0300985812471541"],"URL":"https:\/\/doi.org\/10.1177\/0300985812471541","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,26]]}}}