{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:26Z","timestamp":1787018786529,"version":"build-2736575974"},"reference-count":35,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T00:00:00Z","timestamp":1371772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>Hibernomas are uncommon benign tumors of brown fat that occur in humans and various animal species. They have not been observed in the orbit of dogs, humans, or other animals. Here we report clinical, light and electron microscopic, and immunohistochemical features of a series of 7 hibernomas arising in the orbital region of dogs. These neoplasms occurred in adult dogs with no breed predilection. The mean age of the affected dogs was 10.4 years (range, 8\u201313 years). All neoplasms presented as soft lobular masses composed of predominantly round or polygonal neoplastic cells with granular eosinophilic and vacuolated cytoplasm resembling adipocytes. The cytoplasm contained large numbers of pleomorphic mitochondria with dense matrices and indistinct cristae. Immunohistochemical evaluation confirmed positive labeling of neoplastic cells from all cases with uncoupling protein 1 (UCP-1) consistent with brown fat differentiation. Interestingly, rare neoplastic cells also expressed myogenin and myoD, possibly suggesting a common progenitor cell for neoplastic brown adipose and skeletal muscle cells.<\/jats:p>","DOI":"10.1177\/0300985813493913","type":"journal-article","created":{"date-parts":[[2013,6,22]],"date-time":"2013-06-22T20:10:44Z","timestamp":1371931844000},"page":"563-568","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Clinical, Morphologic, and Immunohistochemical Features of Canine Orbital Hibernomas"],"prefix":"10.1177","volume":"51","author":[{"given":"M.","family":"Ravi","sequence":"first","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin\u2013Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. S.","family":"Schobert","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin\u2013Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kiupel","sequence":"additional","affiliation":[{"name":"Diagnostic Center for Population and Animal Health and Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. R.","family":"Dubielzig","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin\u2013Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,6,21]]},"reference":[{"key":"bibr1-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1177\/0192623308317424"},{"key":"bibr2-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1177\/0192623309335061"},{"key":"bibr3-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2003"},{"key":"bibr4-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.23.10774"},{"key":"bibr5-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjp035"},{"key":"bibr6-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20975"},{"key":"bibr7-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr0809610"},{"key":"bibr8-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200106000-00014"},{"key":"bibr9-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(83)80139-7"},{"key":"bibr10-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1988.254.1.C175"},{"key":"bibr11-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001880404"},{"key":"bibr12-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1007\/BF02425949"},{"key":"bibr13-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1007\/BF00422121"},{"key":"bibr14-0300985813493913","first-page":"300","volume":"31","author":"Jiang RJ","year":"2010","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"bibr15-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2010.64"},{"key":"bibr16-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2009.04.020"},{"key":"bibr17-0300985813493913","first-page":"152","volume":"39","author":"Merkel H","year":"1906","journal-title":"Beitr Pathol Anat"},{"key":"bibr18-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1177\/030098588502200605"},{"key":"bibr19-0300985813493913","first-page":"137","volume":"42","author":"Nagase I","year":"1994","journal-title":"Jpn J Vet Res"},{"key":"bibr20-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(00)00247-4"},{"key":"bibr21-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013512107"},{"key":"bibr22-0300985813493913","first-page":"137","volume":"62","author":"Ochoa R","year":"1972","journal-title":"Cornell Vet"},{"key":"bibr23-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1177\/030098589303000211"},{"key":"bibr24-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1080\/01926230490505086"},{"key":"bibr25-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860601)57:11<2207::AID-CNCR2820571122>3.0.CO;2-#"},{"key":"bibr26-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.16.7561"},{"key":"bibr27-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2006.10.003"},{"key":"bibr28-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e318050ca52"},{"key":"bibr29-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1177\/030098589403100221"},{"key":"bibr30-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610615104"},{"key":"bibr31-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a124728"},{"key":"bibr32-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.05.053"},{"key":"bibr33-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1016\/0248-4900(94)90021-3"},{"key":"bibr34-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2007.00555.x"},{"key":"bibr35-0300985813493913","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1915"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985813493913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985813493913","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985813493913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:53:39Z","timestamp":1777661619000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985813493913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,21]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1177\/0300985813493913"],"URL":"https:\/\/doi.org\/10.1177\/0300985813493913","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,21]]}}}